Evaluation of Post-operative Pain and Bacterial Load Reduction After Incorporation of Mesoporous Silica Nanoparticles in Calcium Hydroxide Intracanal Medicament in Mandibular First Molar Teeth With Necrotic Pulp. "Randomized Controlled Clinical Trial"
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Post-operative pain after application of different intracanal medications
研究概览
简要总结
This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp. It tests whether adding mesoporous silica nanoparticles-antibacterial particles-to calcium hydroxide makes the treatment more effective. Forty-two adult patients will be randomly assigned to receive either calcium hydroxide alone, nanoparticles alone, or a mix of both for one week during root canal therapy. measure patients' pain levels after 6h,12h,24,48h and 72 hours from treatment and the number of bacteria before and after treatment to see which method gives the best results. The goal is to make root canal treatments more comfortable and successful for future patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion Criteria:
- •Patients with an age range between 18 to
- •No sex predilection.
- •Patients with necrotic pulp.
- •Patients able to sign informed consent.
- •Restorable teeth.
- •Positive patient's acceptance for participating in the study.
- •Type III distal and mesial canal of first mandibular molar.
排除标准
- •Pregnant females
- •Medically compromised patients.
- •Patients having analgesics before the treatment
- •If antibiotics have been administrated during the past two weeks pre-operatively.
- •Patients having bruxism or clenching
- •Patients having sever malocclusion associated with traumatic occlusion.
- •Teeth that have:
- •Peri-apical radiolucency
- •Root resorption.
- •Pulp stones or calcifications.
- •Previous endodontic treatment.
结局指标
主要结局
Post-operative pain after application of different intracanal medications
时间窗: from 6 to 72 hours from the treatment
measuring Post-operative pain by Numerical rate scale and pain level will be assigned to one of 4 categorical score: none(0) - mild(1-3), severe(7-10) after 6h,12h,24,48h
次要结局
- bacterial load change after intracanal medication(immediately in the intervention and after 1 week)
研究者
raneem mohamed
principal investigator
Future University in Egypt