NL-OMON55267招募中不适用
DIagnostic and prognostic precision (Algorithm) medicine for behavioral variant frontotemporal dementia - DIPPA-FTD
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •1. Retrospective cases
- •- possible and probable behavioural variant of Frontotemporal dementia (bvFTD)
- •patients (meeting criteria of Rascovsky et al, 2011) or definite non
- •familial/sporadic bvFTD cases .
- •- late-onset Primary Psychiatric cases (onset after 45 years);including Major
- •depressive disorder, single/ recurrent/ persistent (ICD 10 F32, 33, 34),
- •Bipolar disorder (ICD 10 F 31), Manic episode (ICD 10 F30), Schizophrenia,
- •schizotypical disorder (ICD 10: F20, F21), Delusional disorder (ICD 10: F22),
- •Schizoaffective disorder (ICD 10: F25) and Obsessive-compulsive disorder (ICD
- •10: 42) according to the DSM5 criteria. .
- •All above mentioned patients have undergone thorough clinical work-up,
- •according to the respective national protocols, including neuropsychiatric
- •examination, neuropsychological exam, MRI of the brain, DNA, and blood
- •sampling. Follow-up duration was at least one year, and a substantial
- •proportion had a follow-up duration of two years or more.
- •2. Prospective clinical cohort.
- •We will enroll new cases with:
- •- possible and probable bvFTD (meeting criteria of Rascovsky et al, 2011)
- •- ambiguous cases (suspect of bvFTD, but not completely fulfilling criteria).
- •- late-onset PPD diagnosis; including Major depressive disorder, single/
- •recurrent/ persistent (ICD 10 F32, 33, 34), Bipolar disorder (ICD 10 F 31),
- •Manic episode (ICD 10 F30), Schizophrenia, schizotypical disorder (ICD 10: F20,
- •F21), Delusional disorder (ICD 10: F22), Schizoaffective disorder (ICD 10: F25)
- •and Obsessive-compulsive disorder (ICD 10: 42) according to the DSM5 criteria.
- •All cases will be kept in follow-up and will have repeated clinical
- •examinations, plasma sampling and MRI of the brain at baseline and after 1
- •3. Pathologically verified cohort.
- •Dutch and Australian subjects are invited into brain donation programs.
- •In addition, we include pathologically verified patient cohort of
- •FTD and PPD cases from the Netherlands and Australian Brain Banks (The
- •Netherlands: FTLDtau, n=40; FTLD-TDP, n=54; schizophrenia n=13; bipolar
- •disorder n=34; depression, n=40; Australia: FTLD-tau, n=112; FTLD-TDP, n=42;
- •schizophrenia plus matched controls, n=37; depression plus matched controls,
- •n=10). During the course of our project, we will keep collecting donated
- •brains from subjects with FTD, PPD, and ambiguous cases.
排除标准
- •- Mini-mental State Exam score (MMSE) no more than 18
- •- Traumatic brain injury
- •- Drugs or alcohol abuse
- •- Lack of reliable informant
- •- Familial form of bvFTD, defined as genetic or familial bvFTD
- •- Patient declined genetic testing offered as part of standard clinical
研究者
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