ITMCTR2200006487尚未招募未知
oncology
XiyuanHospital of CACMS0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 性别
- All
入选标准
- •(1) 18-85 years old, regardless of gender;
- •(2) It was pathologically diagnosed as colorectal cancer and its clinical stage was stage IV;
- •(3) Patients who intend to receive the standard third-line treatment of Western medicine or have begun to receive the third-line treatment (no more than 14 days);
- •(4) ECoG 0-2 points;
- •(5) Estimated survival period = 3 months;
- •(6) Measurable lesions meeting RECIST 1.1 standard;
- •(7) No strict center of gravity, abnormal lung, liver and kidney functions;
- •(8) Normal coagulation function, no active bleeding and thrombosis;
- •(9) Voluntarily join the study and sign the informed consent form;
- •(10) It is expected that the patients with good compliance can follow up the efficacy and adverse reactions according to the protocol requirements.
- •(11) The researchers believe that they can benefit from this treatment.
排除标准
- •(1) Patients with brain metastases with clinical symptoms;
- •(2) Combined with other untreated malignant tumors;
- •(3) Patients with dmmr by immunohistochemistry or MSI-H by gene detection;
- •(4) Patients with uncontrollable hypertension who cannot be reduced to the normal range after antihypertensive drug treatment (systolic blood pressure = 140mmhg/ diastolic blood pressure = 90mmHg);
- •(5) Suffering from uncontrolled cardiac clinical symptoms or diseases, such as a.nyha II and above heart failure; b. Unstable angina pectoris; c. Myocardial infarction occurred within 1 year; d. Patients with clinically significant supraventricular or ventricular arrhythmias requiring clinical intervention;
- •(6) There are many factors that affect the absorption of oral drugs, such as inability to swallow and intestinal obstruction;
- •(7) Patients at risk of bleeding, including the following: A. active peptic ulcer lesions; b. Those with history of melena and hematemesis within 3 months; c. Hemoptysis occurred within 1 month before entering the study;
- •(8) Patients with thrombotic diseases or receiving anticoagulant drugs; Long term anticoagulation therapy with warfarin or heparin or long-term antiplatelet therapy (aspirin = 300 mg/ day or clopidogrel = 75 mg/ day) is required;
- •(9) Major surgery, open biopsy or significant trauma were performed within 28 days before enrollment;
- •(10) Patients who will or are participating in other clinical trials;
- •(11) Other situations that the researcher thinks are not suitable for inclusion.
研究者
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