Impact of Different Genetic Polymorphism on the Pulmonary Pressure in Patients With Pulmonary Hypertension of Different Cause With Special Focus on Patients With Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Correlation of the Expression of Glu 298ASP Polymorphism with pulmonary pressure
研究概览
简要总结
Pulmonary Hypertension (PH) is a disease that is characterized by vasoconstriction of small vessels of the lung. Many cases do have proliferation of endothelial cells within these vessels. A possible influence of polymorphisms of genes relevant for inflammatory and endothelial processes is suspected.
Especially patients with chronic heart failure can develope PH. The reasons therefore are lacking.
The researchers investigate different polymorphism and the influence of these on pulmonary artery pressure (measured invasively) in patients with congestive heart failure (CHF) and patients with primary pulmonary hypertension.
详细描述
The study consists of 3 arms-patients with CHF and PH, patients with CHF without PH and patients without CHF and PH.
The PH measurement is due to routine catheterization, thereafter we measure different vasoactive polymorphism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CHF with or without pulmonary hypertension or
- •patients with normal LVEF and pulmonary hypertension
- •right heart catheterization due to routine
- •informed consent
排除标准
- •no right heart catheterization
- •no informed consent
- •elevated pulmonary pressure due to valve diseases or congenital heart disease
结局指标
主要结局
Correlation of the Expression of Glu 298ASP Polymorphism with pulmonary pressure
时间窗: Dec. 2010
次要结局
- Rate of G308A TNF alpha polymorphism within the different groups(Dec. 2010)
研究者
Sven Möbius-Winkler
PI
University of Leipzig