A prospective, parallel-group randomized controlled trial comparing an exercise versus control intervention across a range of cannabis detoxification outcome measures during a 7-day inpatient admission

niversity of Sydney0 个研究点目标入组 80 人开始时间: 2015年3月5日最近更新: 2020年1月13日

试验速览

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•(a) At least 18 years of age,
•(b)meets ICD-10 criteria for cannabis dependence,
•(c)reports significant cannabis withdrawal symptoms in previous periods of abstinence,
•(d)capacity to tolerate moderate exercise, and
•(e) willing and capable of providing informed consent to the study procedures.

•(a) Alcohol dependence (and associated alcohol withdrawal sequel by clinical assessment);
•(b) Regular use of other drugs (excluding caffeine, alcohol, and tobacco) or injecting drug use more than once per week on average in previous 28 days;
•(c) Any Drug and Alcohol treatment in the last 28 days;
•(d) Significant medical conditions impacting upon exercise capacity, metabolism and excretion of cannabinoids, or assessment of cognition and performance (including severe cardiovascular, neurological, hepatic, renal, respiratory and endocrine disorders; or haematological conditions:
•(e) Active and severe psychiatric disorders that warrant immediate psychiatric treatment (outside of experimental trial conditions), impact upon capacity for consent, or assessment of outcomes, such as psychosis, suicidality, delirium and severe affective disorders (mild or moderate levels of depression or anxiety not excluded);
•(f) Use of medications that may impact upon the metabolism and excretion of cannabinoids (e.g. CYP450 enyzme inducers/inhibitors), or may impact upon measurement of withdrawal features (e.g. mood stabilisers, sedatives); and
•(g)Pregnancy (plasma hCG screen in women of child bearing potential).

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