Motor Signature, Falls Risk, and Home-Based Interventions in Older Adults With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 入组人数
- 252
- 试验地点
- 2
- 主要终点
- Mattis Dementia Rating Scale (MDRS)
研究概览
简要总结
A single-blinded, randomized controlled trial is designed to compare the effects of social interaction, computerized cognitive training, lower extremity strengthening, and tai chi chuan on improving cognitive functions and gait/mobility and reducing falls among 228 subjects with mild cognitive impairment, in which the influence of adherence to the intervention programs will also be examined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 65 Years 至 100 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 65 years old
- •Had a fall at least 3 months prior to the baseline assessment
- •Can ambulate independently
- •Has mild cognitive impairment
排除标准
- •Cannot ambulate independently and communicate with researchers
- •Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia)
- •Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)
结局指标
主要结局
Mattis Dementia Rating Scale (MDRS)
时间窗: 12 months
The Mattis Dementia Rating Scale (MDRS) contains five cognitive domains of attention, initiation/perseveration, construction, conceptualization, and memory, which specifically assess concentration, verbal fluency, visuospatial skills, analogical reasoning, and short-term memory, with score ranges for these domains of 0\~37, 0\~37, 0\~6, 0\~39, and 0\~25 points, respectively, and a total score range of 0\~144 points.
balance
时间窗: 12 months
The Tinetti balance score ranges 0\~26, with a higher score indicating a better balance ability.
falls
时间窗: 12 months
number of falls and multiple falls
mobility
时间窗: 12 months
The timed up and go test requires subjects to rise from a standard chair, walk a distance of 3 m, turn, walk back to the chair, and sit down. The time to complete the timed up and go will be recorded.
modified Telephone Interview of Cognitive Status (TICS-M)
时间窗: 12 months
The modified Telephone Interview of Cognitive Status (TICS-M) consists of the date of the interview, age, phone number, immediate and delayed word list recall, counting backward, responsive naming, word opposites, and repetition, with a total score range of 0\~50.
次要结局
- fear of falling(12 months)
- depressive symptoms(12 months)
- activity of daily living (ADL)(12 months)