NL-OMON49887招募中2 期
CXCR4-directed [68Ga]Ga-PentixaFor PET/CT vs AVS performance in a diagnoStic randomized Trial Ultimately comparing hypertenSion outcome in primary aldosteronism - CASTUS-Trial
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 228
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational invasive
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- The patient has a diagnosis of primary aldosteronism, confirmed by an
- •elevated aldosterone/renin ratio (ARR) and an intravenous salt-loading test
- •(according to the Endocrine Society guidelines)(1)
- •- Patients who fall in the *grey area* according to the Endocrine Society
- •guidelines (1), will be discussed with all site investigators before inclusion
- •to reach consensus on the diagnosis before inclusion.
- •- Age over 18 years at time of consent
- •- Signed informed consent
排除标准
- •- Refusal by the patients to undergo AVS, [68Ga]Ga-PentixaFor PET/CT, CT, or
- •adrenalectomy
- •- Suspicion of familial hyperaldosteronism type 1, type 2, type 3 or type 4
- •- Suspicion of adrenocortical carcinoma
- •- Severe comorbidity potentially interfering with treatment or health-related
- •quality of life
- •- Requirement of medication interfering with the study protocol
- •- Any medical condition present that in the opinion of the investigator will
- •affect patients* clinical status.
- •- Pregnancy or lactation
- •Estimated glomerular filtration rate (eGFR) kleiner dan 40 ml/min/1.73m²
研究者
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