Cost and Medical Care of Patients With Advanced Serious Illness in Singapore (COMPASS) Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 600
- 试验地点
- 2
- 主要终点
- Change in overall quality of life among patients through the last year of life.
研究概览
简要总结
Cost and Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS),is a cohort study which aims to capture health care utilization, cost, and quality of life indicators of patients with advanced cancer and their primary caregivers.
详细描述
The study will recruit 600 patients with advanced cancer, their primary informal caregivers and their treating physicians. Eligible patients will be recruited from study-sites in Singapore and will be followed until death. Patients and their consenting primary informal caregivers will be interviewed first at baseline and then every 3 months thereafter until the patient's death. A post-death interview with primary informal caregiver will be conducted at 8th week and 6 months after the patient's death. As the majority of the care during last year of life is provided by hospices, the eligible patients will be followed as they receive treatment and care at various hospices. Treating physicians of the patients will be invited to take part in the study. They will be asked to answer a survey conducted only once during the duration of the study.
Data on medical expenditures incurred by a patient from diagnosis of advanced cancer until death will be collected. With patient consent, these data will be extracted every 6 months from the time of patient enrolment from relevant databases, including hospitals and hospices.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Change in overall quality of life among patients through the last year of life.
时间窗: From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
We will assess patient's quality of life through FACT-G
Change in pain severity among patients through the last year of life
时间窗: From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
We will assess pain reported by patients through visual analog pain scores
Change in activities of daily living among patients through the last year of life
时间窗: From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
We will assess limitations in activities of daily living of patients through OARS Multidimensional Functional Assessment Questionnaire
Change in anxiety and depression among patients through the last year of life
时间窗: From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
We will assess patients' anxiety and depression through the Hospital Anxiety and Depression Scale (HADS).
Change in patient's perceived quality of care during the last year of life
时间窗: From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
We will describe patients' assessment of their own care using a scale used by Ayanian et al (JCO, 2010) that consists of 13 questions.
Total health care expenditure during the last year of life through analysis of medical bills
时间窗: From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
We will calculate total health care expenditure during the last year of patient's life as the sum total of expenditures incurred at clinics etc.
次要结局
- Change in patient's awareness of prognosis by asking if the patients believe that their current treatment regimen is likely to cure them of cancer(From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months))
- Change in caregiver's levels of emotional distress through the last year of life(From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months))
- Caregivers bereavement adjustment assessed after patient's death(6 months bereavement)
- Change in caregiver burden through the last year of life(From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months))
- Caregiver's perception of patient's end-of-life care assessed after patient's death(8 weeks bereavement)
研究者
Eric A. Finkelstein
Professor
Duke-NUS Graduate Medical School