Effect of Chemotherapy on Coagulation Profile in cases of Breast Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Changes in values of -
研究概览
简要总结
Cancer is associated with increased risk of thrombosis. Up to 15% of patients with clinically overt cancers present with venous thromboembolism during the course of their disease. breast cancer is the most common site specific cancer in women. an increased incidence in these thromboembolic events have been noted in women receiving chemotherapy.
The main mechanisms of thrombus formation associated with chemotherapeutic agents are-
-
the release of procoagulants and cytokines from the tumour cells damaged by the cell targeted treatment
-
a toxic effect towards the vascular endothelium
-
The fall of naturally occurring anticoagulants
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- Female
入选标准
- •All cases of breast carcinoma.
排除标准
- •1 patients who are unwilling to participate 2 Patients unwilling to participate.
结局指标
主要结局
Changes in values of -
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
Platelet count
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
PT INR
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
APTT
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
D Dimer
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
Bleeding Time
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
Clotting time
时间窗: 1 Before starting chemotherapy | 2 On Day 3 post chemotherapy | 3 On day 14 post chemotherapy
次要结局
未报告次要终点
研究者
DR Wahida Iyamin Hussain
Silchar Medical College and Hospital