Effect of Dipeptidyl-4 Inhibitors in Reducing Stroke Severity, From the Health Insurance Review and Assessment Service Database
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 22,119
- 主要终点
- 1-year survival rate
研究概览
简要总结
The goal of this observational study is to compare severity and mortality rates of acute cerebral infarction(requiring thrombolysis or endovascular recanalization) depending on the type of oral antidiabetic drug taken before the onset of cerebral infarction.
Researchers will compare the group that used DPP-4 inhibitors as anti-diabetic drugs before cerebral infarction and the group that did not use them to see the effect of DPP-4 inhibitors in reducing severity of cerebral infarction.
详细描述
This is a retrospective study to see the effects of reducing the severity of cerebral infarction(requiring thrombolysis or endovascular recanalization) of DPP-4 inhibitors by comparing the survival rate after acute cerebral infarction hospitalization, discharge rate to home, and medical cost.
A. Severity of cerebral infarction and poor prognosis is mainly associated with hyperglycemia caused by diabetes, which increases the Infarction volume and hemorrhagic trasformation.
B. However, the effect of loergin blood glucose on reducing the Infarction volume and improving prognosis of cerebral infarction has not been proven.
C. Preclinical studies have demonstrated a anti-stroke effect that reduces the Infarction volume using certain anti-diabetic drugs.
D. Therefore, there is a possibility that certain anti-diabetic drugs may reduce the severity of cerebral infarction as a class effect in addition to the effect of blood sugar control.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute cerebral infarction who underwent thrombolysis or endovascular recanalization in Korea between 2014 and 2021
- •Those who have been previously diagnosed with diabetes and are taking oral anti-diabetic drugs
- •Adult (over 19 years of age)
- •The definition of antidiabetic drug use is defined as a case in which an antidiabetic drug was prescribed for at least 2 months before stroke and the duration of treatment for stroke coincided with the prescribed duration of the drug.
排除标准
- •Patients taking insulin to control diabetes
研究组 & 干预措施
DPP4i
used DPP-4 inhibitors as anti-diabetic drugs before cerebral infarction(requiring thrombolysis or endovascular recanalization) Combination therpay is acceptable.
干预措施: Dipeptidyl peptidase-4 inhibitor (Drug)
结局指标
主要结局
1-year survival rate
时间窗: Check the data one year after the onset of stroke.
The survival rates of the DPP-4 inhibitor group and the non-use group are compared 1 year after the onset of severe stroke.
re-hospitalization
时间窗: 1 year after discharge the stroke treatment.
The re-hospitalization rates of the DPP-4 inhibitor group and the non-use group are compared after the onset of severe stroke.
Rate of Intensive care unit treatment
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The Intensive care unit treatment rate of the DPP-4 inhibitor group and the non-use group are compared.
Duration of Stroke care unit
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The duration of Stroke care unit of the DPP-4 inhibitor group and the non-use group are compared.
tracheal intubation period
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The tracheal intubation period of the DPP-4 inhibitor group and the non-use group are compared.
90-day survival rate
时间窗: Check the data 90-day after the onset of stroke.
The survival rates of the DPP-4 inhibitor group and the non-use group are compared 90-day after the onset of severe stroke.
frequency of cerebral hemorrhage
时间窗: Hospitalization period and 1 year after discharge the stroke treatment.
The frequency of cerebral hemorrhage rates of the DPP-4 inhibitor group and the non-use group are compared after the onset of severe stroke.
Duration of Intensive care unit
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The duration of Intensive care unit of the DPP-4 inhibitor group and the non-use group are compared.
Rate of Stroke care unit treatment
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The Stroke care unit treatment rate of the DPP-4 inhibitor group and the non-use group are compared.
total hospitalization days
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The total hospitalization days of the DPP-4 inhibitor group and the non-use group are compared.
medical expenses incurred at the time of hospitalization
时间窗: Hospitalization period is expected to be up to three months. It is not possible to accurately estimate the period of hospitalization due to severe stroke.
The medical expenses incurred at the time of hospitalization of the DPP-4 inhibitor group and the non-use group are compared.
次要结局
- Home discharge rate(At the end of discharge from stroke treatment.)
- medical expenses after discharge from hospital(1 year after discharge the stroke treatment.)
研究者
Seong-Joon Lee
Assistant professor
Ajou University School of Medicine