Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 主要终点
- Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children
研究概览
简要总结
To study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori.
详细描述
o study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori.
our study include 2 patient groups:
- st group included 100 child diagnosed Helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive H.pylori eradication treatment and vitamin D as an adjuvant therapy .
- nd group will also diagnosed Helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive H.pylori eradication treatment only.
Helicobacter pylori treatment :
- amoxcillin on 50 mg/kg/day for 2 weeks
- clarithromycin 20mg/kg/day for 2 weeks
- proton pump inhibitor 1mg/kg/day for 1month Vitamin d dose..1000unit /day for 1 month
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 4 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age:4-18 years children with symptomatic H pylori infection presenting with (epigastric pain, persistent vomiting and hematemesis)diagnosed by upper gastrodeudonoscopy , rapid urease test and histopathologic examination of gastric biopsies from antrum and body of the stomach.
排除标准
- •Patient on vitamine D supplémentation
- •Patient who has defect in vitamin D metabolism (chronic renal and hepatic patients, malabsorption syndromes)
- •Patients who had received treatment of H.pylori previously .
研究组 & 干预措施
Triple therapy therapy and vitamin D3
Vitamin D3 ,1000 unit ,once daily, oral, for 1 month plus the standard triple therapy of H pylori (double antibiotics and proton pump inhibitor)
干预措施: Vitamin D3 (Drug)
Triple therapy therapy and vitamin D3
Vitamin D3 ,1000 unit ,once daily, oral, for 1 month plus the standard triple therapy of H pylori (double antibiotics and proton pump inhibitor)
干预措施: Helicobacter pylori triple therapy (Drug)
Triple therapy only
Standard triple therapy of H pylori
干预措施: Helicobacter pylori triple therapy (Drug)
结局指标
主要结局
Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children
时间窗: Six month
eradication of h pylori in children
次要结局
未报告次要终点
研究者
Shimaa Mohamed Yassin
Doctor
Minia University