How do Alpha Oscillations Shape the Perception of Pain? - An EEG-based Neurofeedback Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Alpha asymmetry index (AAI) during neurofeedback
研究概览
简要总结
Pain is closely linked to alpha oscillations (8 -13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing. Consequently, alpha oscillations might also shape the cerebral processing of nociceptive input and eventually the perception of pain. To test this mechanistic hypothesis, the investigators designed a sham-controlled and double-blind electroencephalography (EEG)-based neurofeedback study. In a short-term neurofeedback training protocol, healthy participants will learn to up- and downregulate somatosensory alpha oscillations using attention. Subsequently, the investigators will investigate how this manipulation impacts experimental pain applied during neurofeedback. Using Bayesian statistics and mediation analysis, the investigators will test whether alpha oscillations mediate attention effects on pain perception. This approach promises causal insights into the role of alpha oscillations in shaping pain, and thereby extends previous correlative evidence. Beyond, it can aid the development of novel, non-invasive modulatory treatment approaches for chronic pain, which are urgently needed.
The prosed study protocol has been granted in-principle acceptance from PLOS Biology and the corresponding registration can be found at the OSF online repository [www.osf.io/qbkj2\].
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Double-blinding will be enabled through the usage of sham conditions which comprise an identical sequence of events as the verum conditions and participant-specific numeric codes encoding the order of conditions. During each session, these codes will automatically (1) determine the predefined training conditions and (2) generate file names. Thus, the experimenter will be blinded during data acquisition as well as during subsequent preprocessing and analysis steps.
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 18-45 years
- •right-handedness (laterality quotient > 60 on the Edinburgh handedness inventory)
- •good command of German
- •written informed consent
- •attendance at both sessions and compliance with instructions throughout the experiment
排除标准
- •pregnancy
- •neurological or psychiatric diseases (e.g., epilepsy, stroke, depression, anxiety disorders)
- •severe general illnesses (e.g., tumors, diabetes)
- •skin diseases (e.g., dermatitis, psoriasis or eczema)
- •current or recurrent pain
- •regular intake of medication (aside from contraception, thyroidal, and antiallergic medication)
- •surgical procedures involving the head or spinal cord
- •side-effects following previous thermal stimulation
- •contact to a person with a SARS-CoV-2 infection within the last 2 weeks
- •current symptoms of a cold or flu
结局指标
主要结局
Alpha asymmetry index (AAI) during neurofeedback
时间窗: During procedure (neurofeedback)
During neurofeedback, brain activity will be recorded continuously and the AAI will be extracted. Subsequently, AAIs will be compared between neurofeedback conditions. Details regarding the complete analysis pipeline can be found at the OSF online repository \[www.osf.io/qbkj2\].
Pain ratings during neurofeedback (NRS; 1: 'no pain' to 100: 'worst tolerable pain')
时间窗: During procedure (neurofeedback)
At the end of each neurofeedback trial, participants will verbally rate the perceived intensity of a cutaneous laser stimulus. Subsequently, pain ratings will be compared between neurofeedback conditions. Details regarding the complete analysis pipeline can be found at the OSF online repository \[www.osf.io/qbkj2\].
Pain-related brain responses during neurofeedback
时间窗: During procedure (neurofeedback)
During neurofeedback, brain activity will be recorded continuously, and the pain-related brain responses will be extracted. Subsequently, pain-related brain responses will be compared between neurofeedback conditions. Details regarding the complete analysis pipeline can be found at the OSF online repository \[www.osf.io/qbkj2\].
次要结局
- Perceived task demand (NRS; 1: 'very low' to 7: 'very high')(After each condition)
- Effort exerted (NRS; 1: 'very low' to 7: 'very high')(After each condition)
- Motivation to participate in the training measured by a numerical rating scale (NRS; 1: 'very low' to 7: 'very high')(Before each session)
- Health-related locus of control (Multidimensional Health Locus of Control Scales, MHLC, minimum score: 3, maximum score: 15)(Before each session)
- Current positive or negative affect (Positive and Negative Affect Schedule, PNAS, minimum score: 10, maximum score: 50)(Before each session)
- General self-efficacy (German version of the General Self-Efficacy Scale, GSE, minimum score: 10, maximum score: 40)(Before each session)
研究者
Markus Ploner
Professor of Human Pain Research
Technical University of Munich