NCT01187342已完成不适用
Depression and Posttraumatic Stress Disorder in Stroke Patients: an Observational Study of Neuro-psychiatric, Cognitive, and MR-Changes Over Time After Stroke
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- occurence of depression (GDS, SKID)
研究概览
简要总结
Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.
详细描述
The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stroke in MCA/AchA territory of striato-capsular (at least 125mm³) or non-striatal (10-100cm³) involvement
- •MR-imaging can be conducted 24-48 hours of onset
- •preserved communication skills
排除标准
- •Patients with psychiatric conditions or medication in the last 4 weeks
- •severe medical conditions
- •limited prognosis
结局指标
主要结局
occurence of depression (GDS, SKID)
时间窗: 90 days
Geriatric Depression Scale, Structured Clinical interview for DSM-IV
次要结局
- change in serumcholine(90days)
- change in saliva cortisol(90days)
研究者
Matthias Endres
Prof. MD
Charite University, Berlin, Germany
研究点 (1)
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