Rutgers University Study of the Genetics of Pulmonary Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Genetic risk variants associated with pulmonary hypertension
研究概览
简要总结
The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.
详细描述
This is an online research study to learn more about how genes affect the risk of pulmonary hypertension. No office visit is required and in return, participants may receive information about their genetic ancestry for free. Population-based echocardiography surveys show that pulmonary hypertension (PH) affects roughly 2-3 % of community-dwelling adults and becomes more common with age. This study will increase our understanding of the genetic basis of breast cancer, which is a crucial step in drug development to improve current treatment options. The study investigators seek a diverse population because diversity among participants maximizes the usefulness of the data. Participants will use our online study portal to answer questions about their health and provide their DNA via a saliva sample using a pre-paid mailer. Participation takes approximately 20 minutes. Participants will be invited to share data from their electronic health records, but this is not required for study participation. The study investigators keep participants engaged with short monthly newsletters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18 years or older
- •currently living in the United States
- •able to understand and follow written instructions in English
- •have access to the internet and a computer, laptop, tablet or smart phone
- •willing to provide written informed consent for participation
- •willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home
- •willing to complete a survey with questions about health related to the study of pulmonary hypertension.
排除标准
- •Age 17 or below
- •Not currently living in the United States
- •Not able to participate in an online research study in English
结局指标
主要结局
Genetic risk variants associated with pulmonary hypertension
时间窗: 2 years
Genetic factors will be measured through whole exome sequencing along with genotyping of common variants, and then correlated with pulmonary hypertension and pulmonary hypertension subtype.
次要结局
未报告次要终点
研究者
Tara Matise, Ph.D.
Distinguished Professor
Rutgers, The State University of New Jersey
