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临床试验/NCT02541097
NCT02541097已完成不适用

Preventing Language Decline in Dementia

Baycrest2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2016年5月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
20
试验地点
2
主要终点
Naming accuracy measured with standard naming tests (e.g., BNT)

研究概览

简要总结

This study will establish factors fundamental to the improvement in communication and quality of life for people with dementia known as primary progressive aphasia (PPA). PPA is a type of dementia in which language declines but other cognitive skills (including memory) are preserved in the first several years after the onset. This makes those in the initial stages of PPA excellent candidates for treatment and creates a window of time (2-7 years) whereby they can lead independent lives with minimal support. However, currently, no communication therapy is available to people with PPA due to the progressive nature of the disorder and lack of awareness of available options for professionals willing to treat it.

Participants with PPA in our study will receive two kinds of therapy for the words they cannot recall spontaneously, and will be trained to maintain them through social interaction. The type of training will be based on the most successful interventions the investigators provided to people with PPA in our previous work. The investigators expect that successful re-learning of forgotten words and practicing them in a group setting will facilitate retention of communication skills leading to greater personal independence and increased/maintained quality of life for people with PPA. Our study represents natural combination of two novel approaches for PPA that ultimately will lead to lower demands on the health care system.

详细描述

The study will establish factors fundamental to the improvement in communication and quality of life for people with dementia known as primary progressive aphasia (PPA). PPA is a type of dementia in which language declines but other cognitive skills (including memory) are preserved in the first several years after the onset (see Mesulam 1982). This makes those in the initial stages of PPA excellent candidates for treatment and creates a window of time (2-7 years) whereby PPA individuals can lead independent lives with minimal support. However, currently, no communication therapy is available to people with PPA due to the progressive nature of the disorder and lack of awareness of available options for professionals willing to treat it.

Naming impairments are omnipresent in PPA. For this reason, anomia will be the focus of our intervention. Participants with PPA in our study will receive two kinds of therapy for the words they cannot recall spontaneously, and will be trained to maintain them through social interaction. The type of training will be based on the most successful interventions the investigators provided to people with PPA in our previous work (active encoding and errorless lerning). The investigators expect that successful re-learning of forgotten words and practicing them in a group setting will facilitate retention of communication skills leading to greater personal independence and increased/maintained quality of life for people with PPA. half of the cohort (randomly determined) will then participate in a communication group where conversations are encouraged and half will attend "non-verbal" group meetings when they will paint, watch movies and engage in other activities not requiring talking. To evaluate the benefits of practicing the re-learned words in a social setting naming skills will be tested for each participant before and after individual and group interventions.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

性别
All
接受健康志愿者

入选标准

  • diagnosis of PPA
  • fluent in English
  • able to see and hear
  • able to participate in individual and group sessions
  • willing to travel to sessions
  • physically independent (if assistive devices needed, must be able to operate them)

排除标准

  • untreated mental conditions
  • neurodegenerative conditions (other than PPA)

研究组 & 干预措施

Language therapy-Individual treatment

Active Comparator

Participants will receive intervention for naming impairment based on either phonological or semantic cues.

干预措施: Language therapy (Behavioral)

Language therapy-Group treatment

Active Comparator

Following the individual therapy, participants will be randomly assigned to either verbal or non-verbal group

干预措施: Language therapy (Behavioral)

结局指标

主要结局

Naming accuracy measured with standard naming tests (e.g., BNT)

时间窗: 4 months

次要结局

未报告次要终点

研究者

发起方
Baycrest
申办方类型
Other
责任方
Principal Investigator
主要研究者

Regina Jokel

Clinician Associate

Baycrest

研究点 (2)

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