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临床试验/NCT06775132
NCT06775132进行中(未招募)不适用

Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes in Singapore Adults

National University of Singapore1 个研究点 分布在 1 个国家目标入组 240 人开始时间: 2025年2月3日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
240
试验地点
1
主要终点
Estimated Glomerular Filtration Rate (eGFR)

研究概览

简要总结

This cross-sectional study aims to investigate the associations between dietary intake, cardiometabolic health markers, and gut microbiota composition in Singapore adults.

详细描述

Diet plays a crucial role in maintaining overall health, and changes in dietary patterns are increasingly recognized as major contributors to chronic disease development. Inadequate dietary intake and poor diet quality have been linked to increased risks of cardiometabolic diseases and disruptions in gut microbiota composition. However, most studies investigating these associations have been conducted on Western populations, and there is a lack of research focusing on Asian populations. Given the genetic, metabolic, and dietary differences between Western and Asian populations, examining these associations in an Asian population is essential for a deeper understanding of population-specific risk factors and health outcomes. Therefore, there is an urgent need to assess the associations between dietary intake, cardiometabolic health, and gut microbiota composition in Asian population.

This cross-sectional study aims to investigate the associations between dietary intake, cardiometabolic health markers, and gut microbiota composition in Singapore adults.

Findings from this study will offer valuable insights into the relationship between diet, cardiometabolic health, and the gut microbiota in this population. In addition, this research may identify specific dietary patterns or nutrients that offer greater benefit for cardiometabolic and gut health. In turn, these findings can contribute to the improvement of current dietary guidelines aimed at promoting better cardiometabolic and gut microbiota outcomes for the broader Singaporean population.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
21 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Able to give informed consent
  • Adults 21-80 years old
  • English-literate
  • Have venous access sufficient to allow for blood sampling as per the protocol
  • No drastic change of diet for the past 1 year
  • If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.

排除标准

  • Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
  • Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
  • Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.

研究组 & 干预措施

Younger population

Age 21-64

Middle-aged and older population

Age 65-80

结局指标

主要结局

Estimated Glomerular Filtration Rate (eGFR)

时间窗: Day 1

The estimated Glomerular Filtration Rate (eGFR) of the subjects will be measured from the blood

Dietary intake

时间窗: Day 7

Use a 3-day food record to document dietary intake

Blood lipid lipoprotein profile

时间窗: Day 1

Total cholesterol, LDL, HDL, and triglyceride concentration in the blood will be measured

Fasting blood glucose

时间窗: Day 1

Glucose concentration in the blood will be measured

Endothelial Progenitor Cell Count

时间窗: Day 1

Endothelial functions are determined by the percentage of endothelial progenitor cells (CD34+/KDR+) expression in peripheral blood mononuclear cells

Fecal short chain fatty acid (SCFA) concentration

时间窗: Day 1

SCFA concentration in the blood will be measured

Blood pressure

时间窗: Day 1

Systolic and diastolic blood pressure (in mmHg) will be measured by a blood pressure monitor.

Fecal zonulin

时间窗: Day 1

Zonulin concentration will be determined from fecal samples of the subjects

Trimethylamine N-oxide (TMAO)

时间窗: Day 1

Trimethylamine N-oxide (TMAO) concentration in the blood will be measured

Fecal bile acids

时间窗: Day 1

Bile acids concentration will be determined from fecal samples of the subjects

Fecal calprotectin

时间窗: Day 1

Calprotectin concentration will be determined from fecal samples of the subjects

次要结局

  • Macular Pigment Optical Density (MPOD)(Day 1)
  • The Global Physical Activity Questionnaire (GPAQ)(Day 1)
  • Sleep quality-Pittsburgh Sleep Quality Index Questionnaire(Day 1)
  • Cognitive function(Day 1)
  • Skin carotenoid concentration(Day 1)
  • The Perceived Stress Scale (PSS-10)(Day 1)
  • The Beck Anxiety Inventory (BAI)(Day 1)
  • The Beck Depression Inventory-II (BDI-II)(Day 1)
  • Visual acuity(Day 1)
  • Visual function questionnaire 25(Day 1)
  • Skin advanced glycation end products (AGE) levels(Day 1)
  • Blood advanced glycation end products (AGE) levels(Day 1)
  • Contrast sensitivity(Day 1)
  • Changes in metabolites found in plasma (plasma metabolomics)(Day 1)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jung Eun Kim

Assistant Professor

National University of Singapore

研究点 (1)

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