Alteration in Hearing Following Accidental Dural Puncture. A Study in Parturients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Post-dural puncture headache
研究概览
简要总结
Headache following accidental dural punction as during epidural analgesia can be severe and sometimes very disabling. The incidence of PDPH is 10-40%, most starting within 48 h of dural puncture. Although spontaneous resolution of headaches is common in most patients within 7 days, in 20% can they be persistent and in some very disabling. The exact reason for the characteristic headache is unknown, but it is believed to be the result of leakage of cerebro-spinal fluid (CSF) from the dural puncture. The greater the leakage of CSF, the more severe and persistent the headache. This is why larger needles (lower gauge) are known to have a higher incidence of PDPH. However, the type of needle also seems to play an important role in the likelihood of PDPH.
Headache following accidental PDPH is very typical as it increases significantly when sitting or standing and often disappears completely on lying down. It is typically located in the back of the head, accentuated by light and often decreases with intake of large quantity of fluids. In many cases, it is self-limiting and most often decreases with time and bed rest.
Diagnosis of PDPH is clinical and sometimes difficult. It is well known that liquor leakage, as following spinal anaesthesia, results in partial loss of unilateral or bilateral hearing that can be detected by oto-acoustic hearing loss. We plan to use this knowledge and test the hypothesis that measurement of hearing loss may be a diagnostic method for confirmation of clinical symptoms and signs of accidental PDPH.
详细描述
Parturients who have received epidural analgesia during labour would be included in this study and these would comprise of:
- patients without clinical symptoms of postdural puncture headache
- patients with clinical symptoms of postdural puncture headache
In addition, a control group of parturients who have not received an epidural analgesia would constitute the control group.
All patients would have audiometry (oto-acoustic emission - OAE, and auditory steady state response - ASSR) done following diagnosis of PDPH. Subsequently, the patients would be observed for 24 h to assess whether the headache resolves spontaneously. A new audiometry would be done at this stage. Those patients with substantial evidence of PDPH at this stage would receive an epidural blood patch (EBP) and a new audiometric assessment would be made after 4 h and 24 h to assess whether any audiometric deficit has resolved or not. All patients would have a similar measurement of hearing after 3 months when it is believed that most patients have returned to normal hearing. In addition to audiometric analysis, patients would be asked to fill out a detailed PDPH questionnaire at the same time periods.
All measurements would be compared with patients who have received an EDA but without PDPH and those who have not received an EDA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy parturients No known hearing problems Understand Swedish language Informed consent
排除标准
- •Taking steroid medication Having pre-eclampsia
结局指标
主要结局
Post-dural puncture headache
时间窗: 4 h after epidural blood patch
VAS pain (headache) 4 h after application of EBP
次要结局
- Recurrence of Headache(24 h after application of EBP)
- Audiometric data(4 h following EBP)
- PDPH questionnaire(4 h after application of EBP)
研究者
Anil Gupta
Associate Professor
Örebro University, Sweden
