NCT01589198已完成不适用
Identification of Molecular Biomarkers to Stratify Patients With Refractory Asthma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Determining phenotypes non-invasively
研究概览
简要总结
The purpose of this study is to learn more about asthma in people who are not well-controlled with current asthma medication (refractory asthma). The investigators will compare data from refractory asthmatic patients here at National Jewish Health to mild asthmatics subjects and to people without asthma. Study experiments involve looking at samples from all 3 groups and comparing them at a molecular level. These laboratory experiments may help identify subtypes of refractory asthmatics that require different treatments.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to receive Informed Consent
- •At least 18 years of age
- •ICS < 880 mcg (FP equivalents)
- •PC20<=16 mg/mL
- •No more than 1 oral steroid bursts in previous 12 months
- •Less that 3 urgent care visit in previous 12 months
- •No deterioration with <=25% decrease in steroids
- •No near fatal asthma event
排除标准
- •Pregnancy
- •Current smoker, smoking within the past year or pack/year history >10 years
- •Respiratory infection within past 6 weeks
- •Antibiotics within the past 6 weeks
- •Active lung disease other than asthma
- •Cancer within past 5 years (excluding basal cell skin cancer)
- •Active or chronic infection
- •Hematological or autoimmune disease
- •Unable to safely undergo bronchoscopy as determined by doctor or study doctor
结局指标
主要结局
Determining phenotypes non-invasively
时间窗: October, 2015
Comparing invasive phenotyping to non-invasive
次要结局
未报告次要终点
研究者
研究点 (1)
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