ELECTIVE PARA-AORTIC VS PELVIC ONLY IRRADIATION IN PELVIC NODE POSITIVE CERVICAL CANCER: AN OPEN LABELLED PHASE III RANDOMIZED STUDY [EPIC Study] - EPIC STUDY

Institutional Intramural Funds0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年4月29日

试验速览

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•1) Biopsy proved cancer of Cervix uteri.
•2) Patients with Age more than 18 years or less than 80 years.
•3) With Squamous cell carcinoma, Adenocarcinoma, or Adeno-squamous carcinoma histology.
•4) Patients with FIGO 2018 Stage IIIC1/ TNM cT2b-4a cN1 M0 (Pelvic LN positive cervical cancer)
•established on suitable radiological imaging with atleast one factor:
•Tumor with parametrial invasion (TNM cT2b cN1 M0)
•Tumor extending to lower third of vagina (TNM cT3a cN1 M0)
•Tumor extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney (TNM
•Tumor invading the mucosa of the bladder or rectum (TNM cT4a cN1) with mucosal infiltration
•5) Amenable for Curative Intent treatment.
•6) Fit to receive concurrent chemotherapy.
•7) Suitable for Brachytherapy boost.
•8) Should not be contraindicated for MRI
•9) With Informed patient consent.

•1) Patients age less than 18 years or more than 80 years.
•2) Patients with Significant Para-aortic LN metastasis and/or increased uptake in PET CECT at
•3) Patients with distant metastasis
•4) Previous history of Abdominal or Pelvic radiotherapy
•5) Previous history of partial or total hysterectomy
•6) Patients who received Neoadjuvant chemotherapy
•7) Contraindicated for MRI
•8) Severe medical condition impairing complete treatment delivery
•9) Patients with immunocompromised states and psychological illness
•10) Patients planned only either for EBRT, or Brachytherapy
•11) Pregnant and lactating women

发起方

Institutional Intramural Funds