Effects of Increased Greek Yogurt Consumption on Circulating Markers of Bone Metabolism and Inflammation in Senior Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Serum concentrations of amino-terminal propeptide of type I collagen (P1NP)
研究概览
简要总结
This study aims to examine whether Greek yogurt (GY) consumption will lead to beneficial changes in bone metabolism and inflammation, in senior adults, male and female, when combined with regular exercise (senior fit classes; GYEX) and without exercise (GYNE). It is hypothesized that compared to a control group (senior fit classes, no GY; NYEX), an 8-week GY consumption intervention in senior adults with and without exercise will lead to positive effects on body composition, and markers of bone metabolism and inflammation such that the anabolic and anti-inflammatory markers of these physiological processes will increase more than any training-induced catabolic and pro-inflammatory markers (i.e., more than measures observed in the NYNE group).
详细描述
Participants
The proposed project will follow a randomized controlled parallel design over 8 weeks. A total of 60 senior adults (aged 55+ years; males and females) from the Brock Senior Fit program and Niagara area. All participants will provide written informed consent in order to be included in the study. Potential participants will complete a standardized Get Active screening questionnaire of the Canadian Society for Exercise Physiology. Participants will be excluded from the study if they are injured and unable to participate in classes, have an allergy to dairy foods/dairy protein or have been diagnosed with lactose intolerance.
Study Design and Procedures
Participants will be invited to participate in this 8-week study, with senior fit participants being randomly assigned into the control (NYEX) or the intervention exercising (GYEX) group and non-senior fit citizens from the Niagara community will be assigned to the intervention non-exercising group (GYNE).
Control (NYEX) Group: During the 8-weeks, participants will be instructed to follow their typical, habitual diet and exercise regimen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
盲法说明
Independent blind researchers will analyze blood and data using masked participant codes.
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults 55+ years from from the Niagara area.
排除标准
- •injuries and inability to participate in classes,
- •allergy to dairy foods/dairy protein, or
- •diagnosed with lactose intolerance.
结局指标
主要结局
Serum concentrations of amino-terminal propeptide of type I collagen (P1NP)
时间窗: Weeks 0 and 8
Bone formation marker measured in pg/mL
Serum concentrations of parathyroid hormone (PTH)
时间窗: Weeks 0 and 8
Regulator of bone remodelling measured in pg/mL
Serum concentrations of C-telopeptides of type I collagen (CTX)
时间窗: Weeks 0 and 8
Bone resorption marker measured in ng/mL
Serum concentrations of osteoprotegerin (OPG)
时间窗: Weeks 0 and 8
Regulator of bone remodelling (osteokine) measured in pg/mL
Serum concentrations of irisin
时间窗: Weeks 0 and 8
Myokine measured in pg/mL
Serum concentrations of insulin-like growth factor 1 (IGF1)
时间窗: Weeks 0 and 8
Growth factor measured in pg/mL
Serum concentrations of osteocalcin
时间窗: Weeks 0 and 8
Bone turnover marker measured in picograms/milliliter of serum (pg/mL)
Serum concentrations of sclerostin
时间窗: Weeks 0 and 8
Regulator of bone remodelling (osteokine) measured in pg/mL
Serum concentrations of receptor activator of nuclear factor kappa-Β ligand (RANKL)
时间窗: Weeks 0 and 8
Regulator of bone remodelling (osteokine) measured in pg/mL
Plasma concentrations of interleukin-10 (IL10)
时间窗: Weeks 0 and 8
Anti-inflammatory cytokine measured in pg/mL
Plasma concentrations of interleukin-6 (IL6)
时间窗: Weeks 0 and 8
Inflammatory cytokine measured in pg/mL
plasma concentrations of inflammatory cytokines, including interleukin-6 (IL6), interleukin-10 Plasma concentrations of tumour necrosis factor-alpha (TNFα)
时间窗: Weeks 0 and 8
Pro-inflammatory cytokine measured in pg/mL
次要结局
- Sport-Specific Nutrition Knowledge Questionnaire (GeSNK)(Weeks 0 and 8)
- Height(Weeks 0 and 8)
- Body composition(Weeks 0 and 8)
- Energy intake and expenditure(Weeks 0 and 8)
- Body mass(Weeks 0 and 8)
研究者
Panagiota Klentrou
Professor
Brock University