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临床试验/NCT00760253
NCT00760253已完成不适用

Compare the Side Effects and Differences Awake Level of Propofol by Using Three TCI Formula of Anesthesia in TVOR Patients

National Taiwan University Hospital1 个研究点 分布在 1 个国家目标入组 118 人开始时间: 2008年9月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
118
试验地点
1
主要终点
Vital signs changes and side effects of drugs among groups

研究概览

简要总结

This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.

详细描述

Transvaginal oocyte retrieval (TVOR) is a procedure often used in infertility women . During the procedure, sedation, analgesia or anesthesia are often required. Propofol and alfentanyl are used for these patients for years, but these drugs are used in intravenous form and can be found in follicular fluid. Although further investigation needs to be undertaken to investigate any potential influence on fertilization and implantation rates, we anesthesiologist want to lower the use of drugs in these women. Target-controlled infusion (TCI) pumps can estimate and calculate the target and plasma concentration of propofol. By using these pumps , we can estimate the stable concentration of drugs. Besides, Bispectral index (BIS) monitor can help us to evaluate awareness or unarousable amnesia when we turn lower the drug use and keep patients amnesia during the procedure. Transcutaneous carbon dioxide monitor (tcCO2) can mimic the level of CO2 in patients by using noninvasive method. During anesthesia, CO2 will retain and may induce CO2 nacrosis, so we use these noninvasive method to help us to detect CO2 level preventing CO2 nacrosis and to see if there are any relationship with BIS.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
25 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • ASA physical status I or II women age between 25 and 45 y/o participating to receive TVOR

排除标准

  • Allergy history to alfentanyl, propofol or lidocaine

结局指标

主要结局

Vital signs changes and side effects of drugs among groups

时间窗: pre-anesthesia, post-anesthesia, and one hour post-anesthesia

次要结局

  • Correlation between transcutaneous carbon dioxide and BIS (bispectral index)(From drug infusion stopped to patients awake (per minute))

研究者

申办方类型
Other

研究点 (1)

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