Choroid and Choriocapillary Changes in Polypoidal Choroidal Vasculopathy After Intravitreal Anti-VEGF Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Study of vascular features of choroid in polypoidal choroidal vasculopathy after intravitreal injections of Ranibizumab
研究概览
简要总结
To investigate the structural and vascular features of choroid in patients affected by PCV after Ranibizumab intravitreal injection.
详细描述
Polypoidal choroidal vasculopathy represents a distinct form of choroidal neovascularization.
The study investigated the changes in choroidal vascular network after anti-VEGF therapy using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age older than 60 years
- •diagnosis of polypoidal choroidal vasculopathy
- •absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •absence of significant lens opacities, low-quality OCT-A images.
排除标准
- •age older than 80 years
- •absence of diagnosis of polypoidal choroidal vasculopathy
- •presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •presence of significant lens opacities, low-quality OCT-A images.
研究组 & 干预措施
Patients underwent anti-VEGF therapy
intravitreal Anti-VEGF therapy: Three monthly intravitreal injections
干预措施: Ranibizumab Injection (Drug)
结局指标
主要结局
Study of vascular features of choroid in polypoidal choroidal vasculopathy after intravitreal injections of Ranibizumab
时间窗: 12 Months
The effectiveness of Ranibizumab injections for treating PCV using optical optical coherence tomography angiography. The parameters analyzed by optical coherence tomography angiography were: choriocapillaris vessel density.
次要结局
- Study of structural features of choroid in polypoidal choroidal vasculopathy after intravitreal(12 Months)
研究者
Gilda Cennamo
Principal Investigator
Federico II University