The Role of Complement Factor H Polymorphism in the Regulation of Choroidal Vascular Tone in Young Healthy Subjects
试验速览
- 阶段
- 不适用
- 入组人数
- 220
- 试验地点
- 2
- 主要终点
- Choroidal blood flow during isometric exercise (LDF)
研究概览
简要总结
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Given that it is known that impaired regulation of choroidal vascular tone is present in patients with AMD, the current study seeks to investigate whether genetic polymorphisms in risk alleles for AMD are associated with altered choroidal blood flow regulation in healthy subjects. For this purpose a total of 220 healthy volunteers will be included. Choroidal blood flow regulation will be evaluated by measuring choroidal blood flow during isometric exercise. In addition, flicker induced vasodilatation will be studied and retinal vessel calibers will assessed, as well as retinal thickness and macular pigment optical density.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged between 18 and 45 years, nonsmokers
- •Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- •Systolic blood pressure < 160 mmHg, diastolic blood pressure < 90 mmHg
- •Normal ophthalmic findings, ametropia less than 3 diopters
排除标准
- •Regular use of medication
- •Abuse of alcoholic beverages
- •Participation in a clinical trial in the 3 weeks preceding the study
- •Treatment in the previous 3 weeks with any drug (except hormonal contraceptives)
- •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- •Blood donation during the previous 3 weeks
- •History or family history of epilepsy
- •Pregnancy, planned pregnancy or lactating
结局指标
主要结局
Choroidal blood flow during isometric exercise (LDF)
时间窗: 1 day
次要结局
- Laser Speckle Flowmetry (LSFG)(1 day)
- Retinal vessel calibers and AV- ratio (DVA)(1 day)
- Flicker induced vasodilatation, expressed as percent change to baseline (DVA)(1 day)
- Genotyping (PCR)(1 day)
研究者
Gerhard Garhofer
Ass.Prof.Dr.med.
Medical University of Vienna