Intravenous Atropine in Reducing Reperfusion Arrhythmias, Conduction Abnormalities and Hypotension in Inferior ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 158
- 试验地点
- 1
- 主要终点
- Conduction abnormalities
研究概览
简要总结
People with acute inferior wall myocardial infarction will be given an intravenous drug called atropine that increases the heart rate to check if it prevents heart rhythm disturbances during performing coronary intervention
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute inferior ST elevation myocardial infarction
排除标准
- •Execution of rescur percutaneous coronary intervention after thrombolysis
- •Mechanical complications or no reflow or spontaneous reperfusion.
- •Prior implantation of permanent or temporary pacemakers
- •History of bradycardia, hypotension or ventricular tachycardia with a definitive cause (unrelated to the disease under study)
- •Prior coronary artery bypass graft surgery
- •Atropine contraindications Unwillingness to participate in the
研究组 & 干预措施
Atropine arm
This group will receive intravenous atropine 1 mg immediately before wire crossing
干预措施: Intravenous atropine immediately before wire crossing during primary percutaneous coronary intervention (Drug)
Placebo arm
This group will receive intravenous normal saline immediately before wire crossing
干预措施: Intravenous normal saline as placebo immediately before wire crossing during primary percutaneous coronary intervention (Drug)
结局指标
主要结局
Conduction abnormalities
时间窗: Periprocedurally
Occurrence of conduction abnormalities
Reperfusion arrhythmias
时间窗: Periprocedurally
Occurrence of reperfusion arrhythmias
次要结局
- Major adverse cardiac events(Periprocedurally)