A Randomized Comparison Between Perforator Flap vs Perforator Plus Flap in Myelomeningocele Defect Repair
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- changing hospital stay time
研究概览
简要总结
evaluation of perforator flaps versus perforator plus flaps
详细描述
One of the neural tube defects, myelomeningocele, is a congenital anomaly developing in the fourth gestational week. It is characterized by insertion of neural elements into a pouch floored by meninx through a vertebral defect.
The aetiology is multifactorial. causes are genetic properties, geographic factors, and deficiency of folic acid.
Meningomyelocele incidence range between 1 and 2/1000 live births. The defect location can reside anywhere between the cervical region and the sacrum.
surgical closure of the defect is performed to prevent cerebrospinal fluid leakage and central nervous system infections. it is a combined work between neurosurgery and plastic surgery. Fascial turnover flaps, muscle flaps, local fasciocutaneous flaps.
With the emerging concepts of perforator flaps in the last three decades, the reconstruction of myelomeningocele defects has completely changed since the anatomy of the dorsal intercostal artery perforators (DIAP) and lumbar artery perforators(LAP) has been fully studied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 2 Days 至 1 Year(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •infants up to one year,
- •dorso-lumbar myelomeningocele.
- •moderate to large myelomeningocele defects. (25 - 39 cm2 ) .
排除标准
- •cervical myelomeningocele
- •very large defects (more than 40 cm2 )
- •preterm newborn patients.
- •hematological disease
- •any problem against prone position of the patient
结局指标
主要结局
changing hospital stay time
时间窗: baseline and one month
changing complication rate
时间窗: baseline and 3 months
evaluate of different flaps modalities in back defects closure
次要结局
未报告次要终点
研究者
Mohamed elsayed tawfik
assistant lecturer
Assiut University
