SLCTR/2024/008尚未招募Unknown
A Multicenter, open-labelled, randomized controlled trial to evaluate the efficacy and safety of therapeutic plasma exchange in subjects with snakebite associated thrombotic microangiopathy compared to those receiving standard of care alone
未提供0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.All males and females
- •2. All patients with age equal to more than 18 years
- •2.Patients diagnosed with TMA with or without AKI following RV or HNV bite
- •3.Patients directly admitted or transferred to the hospital within 5 days of the snakebite
- •Criteria used for diagnosis of TMA:
- •TMA is confirmed by the presence of microangiopathic haemolytic anaemia (MAHA) with > 1.0%
- •schistocytes in peripheral blood film examination with absolute thrombocytopenia < 150 x 109 /L or
- •> 25% reduced platelet count from baseline, with or without AKI.
- •At each study site, the local hematologists will be provided with a protocol to identify TMA by
- •recognizing and calculating schistocytes in the peripheral blood
排除标准
- •1. Patients having known allergy to drug prodcuts
- •2.Pregnancy
- •3.Patients having allergic reactions to blood products
- •4.Patients with pre-existing chronic kidney disease with an eGFR <30 ml/min/1.73m2
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