Comparison Between Misopristol and Pitocin After Mifepristone Preparation for Second Trimeter Abortion
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Success rate of abortion
研究概览
简要总结
Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect. The investigators recent study proved the efficacy of pitocin after mifepristone in second trimester abortion with minimal side effects.
Working hypothesis and aims: To compare misopristol and pitocin after mifepristone preparation in second trimester in seccess rate, interval to abortion, side effects and patient satisfaction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •midtrimester late abortion
- •midtrimester induced abortion
排除标准
- •placenta previa
- •infected abortion
- •rupture of membranes
- •s/p cesarean section *2 or more
研究组 & 干预措施
pitocin
high dose pitocin drip 48 hours after mifepristone preparation.
干预措施: mifepristone and oxytocin (Drug)
misopristol
vaginal and oral misopristol 48 hours after mifepristone preparation.
干预措施: mifepristone and misopristol (Drug)
结局指标
主要结局
Success rate of abortion
时间窗: 24 hours
Interval to abortion
时间窗: 24 hours
次要结局
- Side effects(24 hours)
研究者
Assaf Ben Meir
MD
Hadassah Medical Organization