Efficacy of White Tea and Green Tea mouthrinse compared to chlorhexidine mouthrinse against dental plaque, gingivitis and Salivary Streptococcus mutans: A Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- 1.Loe & Silness Gingival Index
研究概览
简要总结
Background: Health benefits of green tea can be attributed to catechins, bio active compounds i.e. polyphenols regarding antioxidant,anti-cancer , anti-inflammatory, anti-bacterial, anti-mutagenic properties. To our knowledge, very few studies on the beneficial effect of white teaon oral health are found in literature.
Aim: To test the efficacy of white tea and green tea in reducing the plaque index (PI) scores,gingival index (GI) and Salivary Streptococcus mutans colony count.
Methodology: A parallel design randomized controlled trial will be conducted among 66 subjects aged 18-35 years. Participants will be randomized into White Tea, Green Tea and CHX group using lottery method. Subjects will be instructed to use 10 ml of provided mouthwashfor 30 secondstwice daily for 3 weeks. Plaque score, gingival score and Salivary S. mutans colony counts will be recorded at baseline and post-intervention (3 weeks).
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- All
入选标准
- •Minimum 20 sound, natural teeth (non-carious)
- •Subjects willing to give an informed consent and follow the schedule.
- •Subjects with good general health.
排除标准
- •Subjects with grossly decayed teeth, full crown or extensively restored teeth or undergoing orthodontic treatment.
- •Subjects with any intraoral soft tissue pathology.
- •Subjects undergoing antibiotic treatment or had it in last one month
- •Subjects using antimicrobial mouthrinses.
- •Subjects consuming a high polyphenol diet (including green tea or soya diet),
- •Subjects wearing appliances, or prostheses (fixed or removable)
- •Subjects with smoking habit.
- •Subjects having history of periodontal treatment within last 3 months.
结局指标
主要结局
1.Loe & Silness Gingival Index
时间窗: At baseline and at 21 day
2.Turesky-Gilmore modification of Quigley Hein Plaque Index
时间窗: At baseline and at 21 day
3.Salivary Streptococcus mutans (S. mutans) colony count
时间窗: At baseline and at 21 day
次要结局
- 1) Staining of teeth – Measured using modified Lobene stain index(2) Taste alteration – Self reported)