euroimaging in central hypersomnolence disorders

CIHR0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•Definite narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia, diagnosed according to the International Classification for Sleep Disorders – Third Edition (ICSD-3) criteria;
•Age between 18 and 65 years old;
•Normal or corrected-to-normal vision;
•Informed consent.
•Healthy controls:
•Age between 18 and 65 years old;
•Normal or corrected-to-normal vision;
•Informed consent.

•Systemic or neurological diseases (e.g., infections, inflammatory disorders, dementia, epilepsy);
•Having worked on night shifts during the last month;
•< 18 or > 65 years of age;
•Major psychiatric disorder (e.g., major depression, psychotic or bipolar disorder);
•History of head injury, encephalopathy, former intracranial surgery, alcoholism or substance abuse;
•Contraindications for MRI exam (e.g., claustrophobia, metallic implants).
•For patients:
•Previous REM sleep behaviour disorder, insomnia, obstructive sleep apnoea or restless legs syndrome diagnosis according to the medical records;
•REM sleep behaviour disorder or restless legs syndrome symptoms at least 1x/month as screened with the Single-Question Screening for REM Sleep Behaviour Disorder and Restless Legs Syndrome Screening Questionnaire.
•For healthy controls:
•REM sleep behaviour disorder as screened by the Single-Question Screening for REM Sleep Behaviour Disorder;
•Restless legs syndrome as screened by the Restless Legs Syndrome Screening Questionnaire (score > 6);
•High-risk for obstructive sleep apnoea according to the Stop-Bang questionnaire (score > 4);
•Insomnia disorder by the Insomnia Severity Index (score > 14);
•Circadian rhythm disorder;
•Short sleepers (< 6 hours on average) or irregular sleep schedules.

发起方