Relationship of Urine Sodium Excretion to Central Blood Pressure and Aortic Pulse Wave Velocity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- the relationship between 24 hour ambulatory blood pressure and 24 hour urine sodium/potassium excretion
研究概览
简要总结
One interesting area is the relationship of high salt intake and central aortic blood pressure. High salt intake is associated development of hypertension and cardiovascular mortality. Central aortic pressure is better correlated with cardiovascular events and mortality. With recent advances in technology, it is possible to measure central aortic pressure noninvasively and easily. Until now there is no study to evaluate the relationship of high salt intake and aortic blood pressure.
The purpose of the present study is to evaluate the relationship of high salt intake and aortic blood pressure and aortic stiffness.
Subjects with or without hypertension will be enrolled for investigation. Subjects with hypertension should be never treated with antihypertensive medications. Subjects with secondary hypertension, diabetes, heart failure, high grade kidney disease, ischemic heart disease, and major arrhythmia will be excluded.
Sodium intake is measured by 24 hour urinary sodium excretion, with the measurement of peripheral and central aortic blood pressure, and aortic pulse wave velocity.
Salt sensitive hypertension related single nucleotide polymorphism will be analyzed to define the relationship with high salt intake and aortic pressure and pulse wave velocity.
详细描述
Measurements: should be performed for 2 days
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24 hour urine Na, K and Creatinine, 24 hour urine amount
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Calculation of urine completeness index : Cr/(21 x Bwt)
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Definition of complete urine collection: complete index ≥ 0.7 and loss not more than one time and 100 mL
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Peripheral blood pressure (pBP)
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Microlife WatchBP Office
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Sitting position
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After 5 minutes resting
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Peripheral systolic BP (pSBP), Peripheral diastolic BP (pDBP),
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Central aortic blood pressure
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SphygmoCor (AtCor Medical, Australia)
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Central systolic blood pressure
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Difference between peripheral SBP and central SBP (SBPp-c)
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Pulse wave velocity
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •subjects without hypertension: n=100
- •subjects with hypertension, not treated at least within 6months: n=100
排除标准
- •secondary hypertension
- •known diabetes (HbA1C >7.5%)
- •night worker
- •stage 3 hypertension
- •renal artery stenosis
- •primary aldosteronism
- •elevated GOT and/or glutamate-pyruvate transaminase > 2 fold of normal range
- •heart failure, significant arrhythmia, angina, myocardial infarction, stroke, carotid stenosis
- •pregnancy
- •autoimmune disease, debilitating disease
- •significant liver disease; active hepatitis, liver cirrhosis
- •alcoholics
- •Renal disease: Cr > 1.2 and/or proteinuria
- •Medication affecting blood pressure and/or vascular stiffness, including lipid lowering agents
结局指标
主要结局
the relationship between 24 hour ambulatory blood pressure and 24 hour urine sodium/potassium excretion
时间窗: cross-sectional study
the relationship between 24 hour ambulatory blood pressure and 24 hour urine sodium/potassium excretion will be analysed. daytime, nighttime and morning BP will be analysed to 24 hour urinary sodium/potassium excretion
次要结局
- the relationship between 24 hour urinary sodium/potassium excretion and central BP and arterial stiffness(Cross-sectional study)
研究者
Moo-Yong Rhee
Professor
DongGuk University