Effectiveness of the use of topical Tetracycline in cutaneous Loxoscelism - ETTCL: EFFECTIVENESS TOPICAL TETRACYCLINE CUTANEOUS LOXOSCELISM

Fundação de Amparo a Pesquisa do estado de São Paulo0 个研究点开始时间: 2019年3月26日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Patients who are victims of skin loxoscelism treated in the State of Santa Catarina will be selected and contacted by the health team and the Toxicological Assistance and Information Center (CIATox-SC) before starting any specific therapy, considering the following diagnostic criteria:
•Typical cutaneous lesion, characterized by the presence of a livedoid (marmoreal) plate, surrounded by ischemic halo, accompanied or not by perilesional blisters, ecchymosis and / or endemic edema, accompanied or not by systemic manifestations;
•2. Atypical cutaneous lesion with suggestive clinical history, excluding other differential diagnoses, with visceral manifestations characterized by hemolysis (to be confirmed by anemia associated with reticulocytosis, elevated bilirubin and LDH), fever, hematuria/hemoglobinuria;
•3. Suggestive history, being the spider captured and the genus identified by CIATox-SC.
•Sample size
•Patients will be randomly divided into two groups: conventional treatment (control) and experimental treatment, in a ratio of 1: 1, for a total of 240 patients.
•Inclusion criteria
•Consecutive patients, of both sexes, over 18 years old, who signed a free and informed consent form with clinical diagnosis of loxoscelism treated at the health units of the municipalities of Santa Catarina, whose contact for diagnosis and therapeutic orientation be done via telephone with CIT-SC.

•Patients who have received or applied any topical treatment for loxoscelism, those who arrive at the service with an indication of surgical procedure of the lesion (debridement of necrotic tissue), as well as the ones who refer atopy or other allergic conditions arising from the use of tetracycline. Also excluded are those who, after the introduction of therapy, have any adverse effects thereof.

发起方

Fundação de Amparo a Pesquisa do estado de São Paulo