Exercise Prebreathe Study in Healthy Adult Volunteers to Evaluate Risk of Decompression Sickness During Simulated Spacewalk Conditions
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 主要终点
- Number of participants with Decompression Sickness
研究概览
简要总结
This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-smoking volunteers aged 30-60 years
- •Able to meet VO2 peak requirements (>35 ml/kg/min males, >30 ml/kg/min females)
排除标准
- •Pregnancy
- •Lung disease, heart disease, hypertension, or diabetes
- •Musculoskeletal pain conditions
- •Requirement for regular medications such as analgesics
研究组 & 干预措施
Single Arm
Participants undergo oxygen prebreathe followed by hypobaric chamber exposure with exercise and monitoring.
干预措施: Oxygen Prebreathe and Hypobaric Exposure (Procedure)
结局指标
主要结局
Number of participants with Decompression Sickness
时间窗: Up to 6 months
Decompression sickness will be recorded during Extravehicular Activity (EVA) simulation at 6.2 psia following a one-hour oxygen prebreathe while resting, performing light exercise or heavier exercise.
次要结局
未报告次要终点