TCTR20200116007Unknown4 期
Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer patient, a randomized controlled trial
ational Science and Technology Development Agency0 个研究点目标入组 396 人开始时间: 2020年1月16日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 396
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- Female
入选标准
- •1)Female patient age > 18 years
- •2)Diagnosis with breast cancer and planned to receive doxorubicin
- •3)Given informed consent
排除标准
- •1Metastatic breast cancer at diagnosis (except lymph node and bone metastasis)
- •2Other malignancies
- •3Prior history of chemotherapy or chest wall radiation
- •4Prior cardiovascular disease with LVEF < 53% or severe valvular heart disease
- •5CrCl < 30 ml/min as measured by Cockcroft-Gault Equation
- •6Patients with baseline EKG show corrected QT interval > 500 msec
- •7Patients currently receiving metformin or donepezil
- •8Allergy or contraindication to metformin or donepezil
- •9Life expectancy < 1 year
- •10Pregnancy and lactating
研究者
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