Evaluation Of Antiplaque Efficacy Of Licorice Extract Mouthrinse & Hypertonic Salt Solution And Their Comparison With Essential Oil & Chlorhexidine Mouthrinses-An Invitro & Invivo Study"
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 主要终点
- Modified Plaque Index
研究概览
简要总结
Periodontal disease is a multifactorial disease caused by mainly bacterial, genetic, immunological, and environmental factors. Chronic periodontitis, one of the widely prevalent forms of periodontal disease, is characterized by loss of attachment apparatus of the tooth; it can lead to tooth loss. Many non surgical and surgical approaches have been adapted time and again to prevent, intercept, and to treat the various forms of chronic periodontitis. But, these treatment modalities are not approachable by all individuals, because of the various factors such as: low socioeconomic status, illiteracy, high cost of the treatment, no availability of easy and uncomplicated treatment nearby etc. Considering these factors, there are still a need of preventive, practical, and affordable treatment options specially for the population of underdeveloped and developing countries.
详细描述
Periodontal disease is a chronic inflammatory process accompanied by destruction of attachment apparatus of tooth and may lead to loss of teeth. It is a multifactorial disease, dental plaque being considered as primary etiologic factor in initiation and progression of disease. Control of periodontal disease by eliminating all pathogenic organisms of the microflora is, as yet, impossible but, it is theoretically an attractive aspect. Based on epidemiological studies there is a very strong correlation between the localization of dentogingival plaque and periodontal disease. Studies have clearly demonstrated that the ability to control the onset or progression of periodontal diseases is improved by regular plaque control practices. Although data shows that oral health can be improved through effective plaque control by mechanical means of cleaning but it fails to deliver optimal levels of oral health because the techniques are not being practiced consistently or thoroughly by all the individuals.
Over the past decade, various antimicrobial compounds have been investigated for their effectiveness to control plaque, but, chlorhexidine digluconate (CHX) is still being considered to be the most effective plaque inhibitor against which other antiplaque agents are measured. Chlorhexidine mouthwash is regarded as Gold standard mouthwash but has many local side effects: extrinsic brown staining of teeth and tongue, taste disturbance, enhanced supragingival calculus formation, desquamation of oral mucosa, and even liver damage in rats.
Cost effectiveness of chlorhexidine also matters especially in underdeveloped and developing countries where prevalence ratio of periodontal diseases are very high. The prevalence of gingivitis and periodontitis, along with their severity and rate of progression is found to vary worldwide; high in developing countries with approximately 80% prevalence in India.
Plant essential oils (EO) have the potential to be used as therapeutic agents for chronic gingivitis and periodontitis conditions that have both bacterial and inflammatory components. These are useful as their long term daily use has no adverse effects on the health of an individual. Also, these are more cost-effective and easily available as over-the-counter products.
It is need of the hour / high time to conduct the research work on various traditional oral hygiene practices / medicines to see their efficacy in the field of periodontics, as various uses of traditional medicine are still untouched & unexplored and few/no any such scientific documents are available, worldwide. And thus, attempts should be made to search for an alternative; Antiplaque, Plaque inhibitory, Anti gingivitis, Host modulating agent, and any other way acting on various levels of prevention of Gingival / Periodontal diseases by using traditional oral hygiene practices/ indigenous products/ homemade remedies/ medicines for maintenance of oral hygiene. Such research work may not only give an alternate antiplaque / plaque inhibitory, and anti-gingivitis agents but, at the same time may give different avenues in imparting treatment modalities on various levels of prevention of Gingival and Periodontal diseases. They may be more effective, more practical, less time consuming, and within the reach of each & every individual of the world in comparison to gold standard 'Chlorhexidine Gluconate Mouthrinse' and various other expensive therapeutic procedures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •General/Medical
- •Any race/ethnic group
- •Aged - 18-30 years
- •Male or female
- •No acute or chronic systemic conditions (see
排除标准
- •No medications/medication history that can interfere with the study (see exclusion criteria below)
- •Non-smoker, Non-alcoholic
- •Who was ready to comply with study procedures
- •Who was available for the duration of the study
- •Who were ready to provide signed informed consent Oral/Periodontal
- •Dentate with at least 14 natural teeth, excluding third molars, that can be evaluated periodontally.
- •Patients with Healthy periodontium and/or Mild Gingivitis.
- •No acute oral diseases (mucosal lesions), oral infections, need for immediate dental/periodontal care (e.g., NUG).
- •Exclusion Criteria:
- •General/Medical A) Any known systemic disease which has effects on periodontium such as diabetes, cardiovascular, cancer etc.
- •B) Volunteers on anti-inflammatory, antibiotics, steroids, cytotoxic, and perioceutics, since 03 months.
- •C) Volunteers who are known allergic to any substance. D) Pregnant and lactating mothers. E) Volunteers who had dental caries. F) Tobacco users (smoke and smokeless) and Alcoholics. G) Volunteers wearing any form of intraoral prosthesis or appliance. Oral/Periodontal
- •<14 teeth that can be periodontally evaluated (excluding 3rd molars)
- •Dental volunteers with compromised periodontal status/ any sign of moderate or severe gingivitis and periodontitis.
- •Acute oral infections.
- •Oral wounds, including recent extractions.
- •Patients with removable or fixed orthodontic appliances
结局指标
主要结局
Modified Plaque Index
时间窗: After 4 days
Modified Plaque Index (Turesky, Gilmore, Glickman modification of Quigely Hein Index, 1970) after disclosing the teeth with two tone solution the PI was recorded. Facial and lingual aspects were scored with PI. Scoring was as follows: 0 - No plaque/debris 1 - Separate flecks of plaque at the cervical margin of the tooth. 2 - A thin continuous band of plaque (up to 1mm) at the cervical margin of the tooth. 3 - A band of plaque wider than 1 mm but covering less than one third of the crown of the tooth 4 - plaque covering at least one third but less than two thirds of the crown of the tooth. 5 - Plaque covering two third or more of the crown of the tooth. Modified Plaque Index = Total score / no. of surfaces examined.
次要结局
未报告次要终点
研究者
Dr. Ruchi Gulati
Post Graduate Student
Government College of Dentistry, Indore
