Clinical Outcomes and Health-Related Quality of Life in Patients Receiving Twice- Versus Thrice-Weekly Maintenance Hemodialysis: A Prospective Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 130
- 主要终点
- Health-related quality of life score
研究概览
简要总结
This prospective cohort study aims to compare clinical outcomes and health-related quality of life between adults receiving established twice-weekly versus thrice-weekly maintenance hemodialysis at Assiut University Hospitals.
详细描述
Thrice-weekly maintenance hemodialysis is the conventional schedule. Twice-weekly hemodialysis is used selectively in patients with residual kidney function. Local prospective comparative data in Egypt are limited.
This observational study will include adults with end-stage kidney disease receiving established twice-weekly or thrice-weekly in-center maintenance hemodialysis. Patients will be followed according to their prescribed schedule without research-driven changes. Health-related quality of life will be assessed using the Arabic KDQOL-36 at baseline, 3 months, and 6 months. Clinical outcomes including adequacy, residual kidney function, hospitalization, and mortality will be recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age 18 years or older
- •Established end-stage kidney disease requiring maintenance hemodialysis
- •Receiving in-center maintenance hemodialysis at Assiut University Hospitals
- •On maintenance hemodialysis for at least one month before enrollment
- •Established twice-weekly or thrice-weekly schedule prescribed by the treating team
- •Clinically stable at recruitment
- •Able to understand and respond to the questionnaire
- •Written informed consent
排除标准
- •- Acute kidney injury without established end-stage kidney disease
- •Hemodialysis for less than one month
- •Peritoneal dialysis or kidney transplantation during follow-up
- •Acute severe illness requiring intensive care at recruitment
- •Severe cognitive, psychiatric or neurological impairment preventing reliable questionnaire responses
- •Active malignancy with expected survival too short to complete follow-up
- •Temporary dialysis solely for an acute indication
- •Refusal to participate
- •Permanent transfer to another dialysis center during follow-up
研究组 & 干预措施
Twice-weekly hemodialysis
Adults receiving established twice-weekly maintenance hemodialysis.
Thrice-weekly hemodialysis
Adults receiving established thrice-weekly maintenance hemodialysis.
结局指标
主要结局
Health-related quality of life score
时间窗: At baseline, 3 months, and 6 months
Mean total score of the Arabic Kidney Disease Quality of Life-36 (KDQOL-36) questionnaire. The KDQOL-36 score ranges from 0 to 100; higher scores indicate better health-related quality of life.
次要结局
- Dialysis adequacy(Up to 6 months)
- Residual urine output(Up to 6 months)
- Hospitalization rate(Up to 6 months)
- Interdialytic weight gain(Up to 6 months)
- Mortality(Up to 6 months)
研究者
Justin George Shawky Youssef
Resident Physician
Assiut University