Target: Identification for High Risk Childhood AML Based on Genome-Wide Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Detailed molecular map of pediatric high-risk acute myeloid leukemia
研究概览
简要总结
This pilot research trial studies biomarkers in bone marrow samples from pediatric patients with high risk acute myeloid leukemia. Studying samples of bone marrow from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
详细描述
PRIMARY OBJECTIVES:
I. To provide a detailed, molecular map of pediatric high risk acute myeloid leukemia (AML).
II. To identify mutations, expression profile, gene copy number, loss of heterozygosity (LOH) status and genomic methylation patterns in order to identify novel changes associated with pediatric AML.
III. To generate fibroblast cell lines in order to obtain germline nucleic acids from marrow specimens from AML patients with induction failure.
IV. To identify genomic alterations contributing to induction failure in childhood AML.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of acute myeloid leukemia
- •High-risk disease
- •Treated on COG-AAML03P1 or COG-AAML0531
- •Meets the following criteria:
- •Initial remission with no known adverse risk factors
- •High quantity and quality of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) available
- •Highly enriched specimens with >= 50% blast available
排除标准
- 未提供
结局指标
主要结局
Detailed molecular map of pediatric high-risk acute myeloid leukemia
时间窗: Baseline
Mutations in identifying novel changes associated with pediatric AML
时间窗: Baseline
Expression profile in identifying novel changes associated with pediatric AML
时间窗: Baseline
Gene copy number in identifying novel changes associated with pediatric AML
时间窗: Baseline
Genomic methylation patterns in identifying novel changes associated with pediatric AML
时间窗: Baseline
Genomic alterations contributing to induction failure in childhood AML
时间窗: Baseline
LOH status in identifying novel changes associated with pediatric AML
时间窗: Baseline
Genomic and transcriptome alterations associated with induction failure
时间窗: Baseline
次要结局
未报告次要终点