Population-based Investigation of Aneurysm Incidence
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4,711
- 试验地点
- 1
- 主要终点
- Specific markers are detected
研究概览
简要总结
Most intracranial aneurysms are found accidentally in neurovascular imaging. And these inspection methods are limited by the problems of instrument fixation, radiation, time-consuming, contrast agent toxicity and so on. At present, blood test is an ideal alternative method for early diagnosis. Compared with imaging examination, it is economical, general screening and convenient. Blood test is simple to operate, easy to be accepted by patients, and less invasive. Early screening of aneurysms can be performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 35-75
- •Individuals with normal cognitive and communication abilities
- •No serious complications, such as uncontrolled hypertension, diabetes or other chronic diseases that may affect the test results.
- •Basic blood test is normal or close to normal range.
排除标准
- •Pregnancy
- •Severe heart disease, renal insufficiency, liver dysfunction and other major diseases.
- •In the past 6 months, there were strokes, or other types of intracranial tumors, infections and other diseases that may affect the screening results.
- •There are metal implants, including dentures, pacemakers, etc.
- •Using or recently used drugs that may affect blood biomarkers ( such as anticoagulant drugs, immunosuppressive agents, etc. ).
- •There are serious mental illness or cognitive dysfunction, such as claustrophobia, unable to cooperate with the completion of the test.
- •It is currently participating in other clinical trials or has participated in other clinical trials in the past 3 months.
结局指标
主要结局
Specific markers are detected
时间窗: 1hours after blood collection
oleic acid, arachidonic acid, docasa-hexaenoic acid, interleukin 1β， interleukin 1ra, tumor necrosis factors, SOD3, PPIA, S100A8, S100A9, MPO, APOA4, THBS1.
次要结局
未报告次要终点
研究者
Wang Shuo
Director of Department of Cerebrovascular Neurosurgery
Beijing Tiantan Hospital