ISRCTN44878718已完成不适用

Age of BLood Evaluation (ABLE) trial in the resuscitation of critically ill patients: a multicentre randomised controlled superiority clinical trial

Sainte-Justine Hospital Research Centre (Centre de recherche du CHU Sainte-Justine) (Canada)0 个研究点目标入组 2,510 人开始时间: 2008年8月22日最近更新: 2015年1月13日

试验速览

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•Patients who:
•1. Have had a request for a first red cell unit transfusion in the Intensive Care Unit (ICU), and
•2. Have an anticipated length of invasive and/or non-invasive continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BIPAP) mechanical ventilation of at least 48 hours once enrolled, as estimated by the attending physician

•Investigators and research assistants will exclude patients:
•1. Who are less than 16 years of age
•2. Who were previously enrolled in the ABLE study
•3. Who have already been transfused with red cells during the current hospitalisation
•4. Who have an obvious terminal illness documented in the medical record with a life expectancy of less than 3 months
•5. Who have undergone routine cardiac surgical care
•6. Where a decision to withdraw/withhold some critical care had been made
•7. Who are obviously brain dead
•Investigators, research assistants and blood bank personnel will also exclude patients:
•8. When there are no red cells with a storage time of 7 days or less available in the blood bank that cannot be transported from the blood supplier
•9. Who require more than 1 unit of uncross-matched red cells
•10. With a known objection to blood transfusions
•11. With autologous blood donations
•12. Who pose difficulties in securing blood products (rare blood groups), and who are difficult to match

发起方

Sainte-Justine Hospital Research Centre (Centre de recherche du CHU Sainte-Justine) (Canada)