ACTRN12608000627358招募中1 期
A Study of APO2L/TRAIL in Combination With Rituximab as a potential treatment in Subjects With Follicular and Other Low Grade, CD20+, Non-Hodgkin's Lymphomas
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- Genentech
- 入组人数
- 105
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 /A（—）
- 性别
- All
入选标准
- •Signed Informed Consent Form
- •Age = 18 years
- •History of histologically confirmed CD20+ follicular Non-Hodgkin's Lymphoma Grade 1, 2, or 3a
- •Progression of disease following the most recent treatment with rituximab-containing therapy that resulted in stable disease or a partial or complete response lasting = 6 months
- •Measurable disease
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- •For subjects of reproductive potential (males and females), use of a reliable means of contraception (e.g., contraceptive pill, intrauterine device [IUD], physical barrier throughout the trial and for 1 year following their final exposure to study treatment).
- •Life expectancy of > 3 months
排除标准
- •Prior radiotherapy to a measurable, metastatic lesion(s) to be used to measure response unless that lesion shows unequivocal progression at baseline
- •Radiation therapy to a peripheral lesion within 14 days prior to Day 1; Radiation therapy to a thoracic, abdominal, or pelvic field within 28 days prior to Day 1
- •Chemotherapy, hormonal therapy, radiotherapy, or immunotherapy within 4 weeks prior to Day 1
- •Patients who have received radioimmunotherapy for relapsed or refractory, follicular NHL are eligible for the study if they received this therapy at least 1 year prior to Day 1, they have adequate bone marrow function, and they have no evidence of myelodysplastic syndrome on bone marrow aspirate/biopsy
- •Prior treatment with Apo2L/TRAIL or an agonist antibody to DR4 or DR5
- •Concurrent systemic corticosteroid therapy
- •Evidence of clinically detectable ascites on Day 1
- •Other invasive malignancies within 5 years prior to Day 1
- •History or evidence upon physical examination of CNS disease within 1 year prior to study entry
- •Active infection requiring parenteral antibiotics on Day 1
- •Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 1 or anticipation of need for major surgical procedure during the course of the study and fine needle aspirations within 7 days prior to Day 1
- •Pregnancy or lactation
- •Serious nonhealing wound, ulcer, or bone fracture
- •Current or recent participation in another experimental drug study
- •Clinically significant cardiovascular disease
- •Known positive test result for HIV, hepatitis B surface antigen (sAg), hepatitis B IgG or IgM core antibody, or hepatitis C antibody
- •Known sensitivity to murine or human antibodies
- •History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates use of an investigational drug or that might affect interpretation of the results of the study or render the subject at high risk from treatment complications
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