A randomized controlled trial of the effect of remimazolam on postoperative QT interval in gynecologic laparotomy

未提供0 个研究点目标入组 120 人开始时间: 2022年9月6日最近更新: 2023年9月29日

试验速览

暂无简介。

•Patients scheduled for genecologic laparatomy
•under general anesthesia
•Patients aged 20 or older
•Patients classified as ASA-PS 1 or 2 (American Society of Anesthesiologists-Physical Status)
•Patients who fully understand the study after sufficient explanations and provide the written volun
•tary consent

•Patients who have contraindication or allergy to sevoflurane or remimazolam
•Patients who have abnormal QT interval in preoperative ECG
•Patients who do not have sinus rhythm in preoperative ECG
•Patients who take antipsychotics, antiarrhythmics, or beta-blockers
•Patients who have hypokalemia (< 3.5 mEq/L) or hyperkalemia (> 5.5 mEq/L) in preoperative labor
•Patients whose BMI are 35 or greater
•Patient who are considered ineligible for enrolling the study by a principal- or co-investigator

Heart-rate corrected QT (QTc) interval after tracheal extubation

Correlation between plasma concentration of remimazolam and QTc
Correlation between plasma concentration of ropivacaine and QTc
QTc interval during induction of anesthesia(during induction of anesthesia)
Hourly QTc inteval from the beggining to the end of surgery(from the beggining to the end of surgery)
QTc interval at postoperative day 1(postoperative day 1)
Incidecne of perioperative fatal arrhythmia through medical record review(perioperative)

发起方

未提供