NCT01737255已完成不适用
Magnetic Resonance Imaging Screening In Li Fraumeni Syndrome: An Exploratory Whole Body MRI Study
Institute of Cancer Research, United Kingdom1 个研究点 分布在 1 个国家目标入组 88 人开始时间: 2012年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Diagnosis of malignant disease
研究概览
简要总结
This study is aimed at exploring the use of whole body MRI for early cancer detection in TP53 mutation carriers and population controls, with the hypothesis that more cancers will be detected in the TP53 mutation carrier group. A secondary end-point will be the number of incidental findings detected and subsequent investigations required. A series of questionnaires will be used to assess the psychological impact of screening on both the study and control group.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Carrier of germline TP53 mutation which, in the view of the geneticist, is not known to be low penetrance OR non-related individual with no personal history of malignancy and no first degree relatives diagnosed with malignancy under the age of 50 years
- •Please note, TP53 carrier cohort is complete and no longer open to recruitment
- •Age between 18 and 60
- •Able to give informed consent
排除标准
- •Individual with low penetrance TP53 mutation
- •Individual with TP53 variant of unknown significance.
- •Previous malignancy diagnosed < 5 years ago in TP53 carriers (except non-melanomatous skin cancer or cervical CIS) Previous history of malignancy in non-related controls (except non-melanomatous skin cancer or cervical CIS)
- •Current symptoms suggestive of malignancy
- •Contraindication to MRI (such as non-MR compatible metal implants) as specified by the standard MR safety checklist
- •Claustrophobia
- •ECOG performance status >2
结局指标
主要结局
Diagnosis of malignant disease
时间窗: Within 12 months of MRI scan
Following MRI scan further investigations may be required to diagnose malignancy
次要结局
- Diagnosis of relevant non-malignant disease(12 months following MRI scan)
- Diagnosis of non-relevant disease, number and type of investigations required(12 months following MRI)
- Psychological impact of MRI screening(12 months following MRI screening)
研究者
研究点 (1)
Loading locations...
相似试验
进行中（未招募）
不适用
Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition SyndromesLi-Fraumeni SyndromeNCT02950987Dana-Farber Cancer Institute150
终止
不适用
Prospective Tumor Response EvaluationHepatocellular CancerMetastatic Liver CancerNCT02787954The University of Texas Health Science Center, Houston10
招募中
1 期
PET/MRI, 18F-FDG PET/CT and Whole Body MRI in Finding Extramedullary Myeloid Leukemia in Patients With Newly Diagnosed Acute Myeloid LeukemiaAcute Myeloid LeukemiaAcute Promyelocytic Leukemia With PML-RARANCT02390635M.D. Anderson Cancer Center77
已完成
不适用
Whole Body Magnetic Resonance Imaging (MRI) for Detection of Cancer MetastasesBreast CancerNCT00592462M.D. Anderson Cancer Center32
撤回
不适用
Magnetic Resonance Imaging (MRI) of Tumor Response and Cognitive Impairment in Breast Cancer Patients Undergoing ChemotherapyBreast CancerNCT01045044Kettering Health Network