Is There a Transient Rebound Effect of Platelet Reactivity Following Cessation of Dual Antiplatelet Therapy With Ticagrelor - a Single Center Prospective Observational Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- platelet reactivity
研究概览
简要总结
to assess whether cessation of 12 months DAPT regimen containing Ticagrelor results in a hyperreactive phase of platelet function
详细描述
the study will be composed of a cohort of patients , who completed 12 months of DAPT with Ticagrelor (standard recommended dose for ACS - 90 mg BID), did not experience any clinical or adverse event during this time period and are about to discontinue Ticagrelor. We intend to measure the platelet reactivity for each patient on 4 time points - prior to cessation of Ticagrelor (i.e. while still on DAPT) and 1,4 and 12 weeks post discontinuation of therapy. There will not be a control group.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •underwent coronary stent implantation due to ACS
- •completed 12 month of DAPT regimen containing Ticagrelor at standard dose (90 mg BID)
排除标准
- •any ischemic or bleeding events while under Ticagrelor
- •any other Ticagrelor associated adverse effects
- •planned for continuation of Ticagrelor for more than 12months post stenting according to the judgment of the attending physician.
- •Unable to make informed consent .
结局指标
主要结局
platelet reactivity
时间窗: from 1 week prior to 12 weeks post DAPT cessation
次要结局
未报告次要终点
研究者
Guy Witberg
Dr Guy Witberg, MD department of cardiology , Rabin medical centre
Rabin Medical Center