Effects of Ramadan Fasting on the Intestinal Microbiota and Fatty Acid Binding Protein 4 (FABP4) of Individuals

Okan University1 个研究点分布在 1 个国家目标入组 15 人开始时间: 2023年3月10日最近更新: 2023年10月27日

适应症

试验速览

阶段: 不适用
状态: Enrolling By Invitation
发起方
入组人数: 15
试验地点: 1
主要终点: LDL-C analysis

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study, which aims to examine the effect of Ramadan fasting on intestinal microbiota composition and FABP4, was designed as a quasi-experimental study.

This study is planned to be conducted with volunteer participants who fasted during the Ramadan and met the inclusion criteria.

详细描述

The sample of the study was determined as 10 volunteer male participants who fasted during the Ramadan and met the inclusion criteria. Participants will not be subjected to any energy restriction, they will be fed ad-libitum and only the effect of intermittent fasting and fasting time on the variables will be examined.

Intermittent fasting is supported by increasing studies showing that it has a purifying effect on health. In particular, fasting practices exceeding 16 hours induce autophagy at the cellular level and this continues its effect in all tissue and organ systems after the regeneration movement that starts at the cellular level.

One of the important factors affected by intermittent fasting is the changes in microbiota, which is closely related to the general health of humans. Microbiota is generally defined as the colonization of certain places in our body by various populations of microorganisms and is affected by many factors such as nutrition, lifestyle, exercise, drug use and stress.

Fatty acid binding protein 4 (FABP4) is an adipocyte member of the fatty acid binding protein (FABP) family with nine different isoforms. It is highly secreted from adipose tissue but is also expressed from monocytes, macrophages and dendritic cells. This adipocyte, which increases in obesity, is found at higher levels in women than in men. Studies have shown that increased serum FABP4 levels are associated with Type 1 and Type 2 diabetes mellitus (DM), insulin resistance, and cardiovascular diseases.

The aim of this thesis study was to investigate the effect of Ramadan fasting on gut microbiota and FABP4.

研究设计

研究类型: Observational
观察模型: Other
时间视角: Cross Sectional

入排标准

年龄范围: 20 Years 至 50 Years（Adult）
性别: Male
接受健康志愿者: 是

入选标准

•Not having a chronic disease diagnosed by a doctor (DM, hypertension, dyslipidemia, cancer, chronic renal failure, GI problems, etc.)
•Being a male between the ages of 20-50
•Body mass index (BMI) > 18.5 and < 34.9 kg/m2
•Not drinking alcohol
•Not having applied any diet program in the last 6 months
•Not taking prebiotic or probiotic supplements in the last 6 months
•Not having used antibiotics in the last 6 months
•Not using nutritional supplements
•Volunteering to participate in the research

排除标准

•Women will not be included in the study due to the fact that they will not be able to fast the entire Ramadan fast due to menstruation.