Personality and Genotypic Markers That Predict Individual Differences in Susceptibility to Stress-induced Alcohol Misuse: a Feasibility Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Alcohol misuse
研究概览
简要总结
To examine whether variation in 'risk-taking' personality and linked genetic variants predicts susceptibility to, and resilience against, stress-induced alcohol misuse.
详细描述
Alcohol misuse is a global health issue responsible for over 1 million hospital admissions per annum in the UK with a combined cost of approximately £21 billion. Chronic alcohol misuse in patients who attend hospital for alcohol-related illness/injury is common, with relapse and recidivism almost ubiquitous. Patients often report that 'stress' was a catalyst for their drinking episodes, but we do not know exactly who is most at risk, how stress leads to drinking, or the genetic basis for this risk. This research aims to seek to identify patients at higher risk of stress-induced alcohol misuse, or who are more resilient to stress in this context, using a combination of analyses ranging from genetic variants to personality tests and clinical follow-up. The ultimate goal is that patients engaging with alcohol services can receive personalised and focussed treatment and enhance recovery
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or Female, aged (min) 18 years
- •Attended Portsmouth Hospitals University Trust following illness/injury related to alcohol use
- •Has a maximum AUDIT score of 15
- •Is willing and able to comply with study procedures
- •Willing and able to give informed consent for participation in the study.
- •Must be recruited within 24 hrs of ASNS referral, and able to be tested within 48 hours of referral
排除标准
- •ny reported/suspected intellectual/learning disabilities (e.g., Down's Syndrome), neurodevelopmental disorders (e.g., Autism, Asperger's) or acquired brain injury
- •Has previously participated in this study
- •Should not be under the influence of alcohol during the study (12hrs previous to taking part) - to be determined via breathalyser.
- •Any history of advanced liver disease (clinical diagnosis of cirrhosis, jaundice, encephalopathy, ascites, variceal haemorrhage)
结局指标
主要结局
Alcohol misuse
时间窗: immediately after the procedure
Measured using the alcohol use disorders identification test (AUDIT) (higher the score the worse the outcome)
Recent stressors
时间窗: Immediately after the study visit
Measured using the 30 item Stress Overload Scale questionnaire (higher the score, the worse the outcome)
Life Events
时间窗: Immediately after the study visit
Measured using the Life Events Checklist Questionnaire (the higher the score the worse the outcome)
Impulse Behaviour
时间窗: Immediately after the study visit
Measured using the the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-P) higher values indicate more impulsive behavior.
Risk taking behaviour
时间窗: Immediately after the study visit
Measured by the Stop Signal Reaction Time Task (computer task) which measures the ability to inhibit a planned response
Molecular Anaylsis
时间窗: Immediately after the study visit
Cheek swabs will be taken from all participant to carry out genomic DNA analysis
次要结局
未报告次要终点