Effects of CLA Supplements on Body Weight and Fat Oxidation
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Fat Mass
研究概览
简要总结
Conjugated linoleic acid (CLA) is form of fat found in dairy foods, beef and other natural sources. When given to small animals, decreases of body fat have been noted.. Although weight loss is the best treatment for overweight and obesity, it is difficult to maintain the loss in the long term. Because of this, treatment emphasis has turned to small weight losses obtained through non-restrictive diets and prevention of weight regain. This is a study to determine if 6 months of consumption a purified form of CLA will result in greater loss of body fat than control and to determine whether CLA consumption increases total fat oxidation, which would help explain why the weight loss occurs.
详细描述
Subjects were screened and then underwent baseline evaluation. The substudy evaluation measured 24-h energy expenditure and substrate utilization by using a whole-room indirect calorimeter. Dietary fat oxidation was measured by mixing [1-13C]oleate and D31-palmitate into a breakfast meal and then collecting breath carbon dioxide and urine to measure the end products of oxidation. Subjects were then provided either 4 g/d of 78% active CLA isomers (3.2 g/d: 39.2% cis-9,trans-11 and 38.5% trans-10,cis-12) or 4 g/d of safflower oil placebo as 1-g gel capsule supplements. The baseline evaluations were repeated 6 mo later.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI 25-29.9 kg/m2
- •Absence of a weight change of greater than 3 kg in the previous 6 months
排除标准
- •Presence of a physical limitation to walking exercise
- •Current or recent (6 months) enrollment in a commercial or self-prescribed weight loss program
- •A history of metabolic disease-ie. renal, endocrine, hepatic or gastrointestinal disease that would impact the outcome of the study
- •A history of a psychiatric or eating disorders Ÿ Presence of metal implants that would interfere with body composition analysis
- •Fasting plasma cholesterol >300mg/dl or triglycerides above 500 mg/dl.
- •Abnormal EKG
研究组 & 干预措施
CLA treatment
The group randomized to Conjugated Linoleic Acid (CLA) treatment at 4 grams per day of 39% cis-9, trans-11 CLA; 39% trans-10, cis-12 CLA; and 22% safflower oil for 6 months
干预措施: conjugated linoleic acid (Drug)
Placebo
The group randomized to control received 4 g/d of safflower oil.
干预措施: conjugated linoleic acid (Drug)
结局指标
主要结局
Fat Mass
时间窗: 6 months
loss of fat mass, kg
次要结局
- Total Fat Oxidation(6 months)