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临床试验/NCT01107210
NCT01107210已完成不适用

Evaluation of Physical Fitness After Stroke: Evolution and Determinants

KU Leuven1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2006年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
KU Leuven
入组人数
50
试验地点
1
主要终点
Evolution of physical fitness after stroke, measured by VO2 peak and OUES.

研究概览

简要总结

This study aims to examine the evolution and determinants of physical fitness after stroke.

详细描述

Stroke is a major cause of chronic severe disability. More than 50% of stroke survivors have residual motor and functional deficits which have an impact on their participation and quality of live (Patel et al, 2006). Limitations on daily functioning may lead to physical inactivity and a sedentary lifestyle. Sustained physical inactivity (deconditioning) induces a reduction in aerobic capacity, which may further increase the risk of cardiovascular diseases in these individuals above that associated with stroke itself. Therefore, improving aerobic capacity may be essential in prevention of secondary diseases due to lack of fitness in the stroke population. Previous studies have also indicated that a critical level of aerobic capacity must be met in order to function independently (Cress et al, 2003). Therefore, in addition to disease prevention, enhancing aerobic capacity in individuals with stroke may also have beneficial effects on promoting functional abilities and independent living. It is also known that a limitation in functional performance is mostly associated with a restriction in social activities (ICIDH-2-model). Clearly, stroke survivors can benefit from counseling on participation in physical activity and exercise training. A recent meta-analysis (Pang et al, 2006) showed that there is good evidence to support the use of aerobic exercise to improve aerobic capacity in individuals with stroke. However, before going on that road, one needs to know more about the level of physical activity and physical fitness in the stroke population.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • first-ever stroke as defined by WHO
  • aged < 75 years,
  • able to comprehend simple oral instructions.

排除标准

  • other neurological impairments with permanent damage
  • stroke-like symptoms due to subdural haematoma, tumour, encephalitis or trauma
  • pre-stroke Barthel Index <50
  • unable to perform a maximal exercise test in accordance with absolute contra-indications for exercise testing (ACC/AHA)
  • no informed consent.

结局指标

主要结局

Evolution of physical fitness after stroke, measured by VO2 peak and OUES.

时间窗: 1y follow-up

The criterion standard of cardiorespiratory fitness (VO2max) will be measured during a graded cycle ergometer test. After three minutes of familiarization, the participants will begin to pedal at 10W, with workload increments of 10W/min; they will be instructed to pedal at a comfortable rate between 30 to 60 rpm. Participants will also be monitored with Borg's 16-point Ratings of Perceived Exertion Scale. Maximal effort will be achieved according the ACSM criteria. If no "true" VO2 peak value could be reached, the Oxygen Uptake Efficiency Slope (OUES)will be determined as dependent variable.

次要结局

  • Determinants at functional, activity and participation level of physical fitness after stroke(1y follow-up)

研究者

发起方
KU Leuven
申办方类型
Other

研究点 (1)

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