SARS-CoV-2 Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 6,000
- 试验地点
- 3
- 主要终点
- SARS-CoV-2 susceptibility in healthcare workers and patients
研究概览
简要总结
The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients.
Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives and serum from the Crick COVID-19 Consortium Testing centre (Cohort A1) and additional biological material collected prospectively (Cohorts A2 and B) will be used for research into SARS-CoV-2 transmission, evolution and immune control. This testing centre is a partnership between UCLH and The Francis Crick Institute to provide COVID 19 RT PCR testing for healthcare workers (HCWs) and patients in London Hospitals and care homes. A third group (Cohort C) of the study will allow for collaborative work with other REC approved research studies that have used the Crick COVID-19 Consortium Testing centre and will involve the use of study samples already collected from each study to be analysed under the SARS-CoV-2 Longitudinal Study end points
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals who have previously provided nasal throat swab samples for SARS-CoV-2 testing at the Crick COVID 19 Consortium Testing centre.
- •≥18 years of age
- •To enrol in the SARS-CoV-2 positive cohort of the study, the participant should have a positive RT qPCR result
- •Employees based at the participating sites including who had their serology and/or swab tested (for recruitment to Cohort B)
- •Participants enrolled in other studies who had their samples processed by using the Crick COVID 19 Consortium Testing centre (for recruitment to Cohort C).
- •Written informed consent (except Cohort A1)
排除标准
- 未提供
结局指标
主要结局
SARS-CoV-2 susceptibility in healthcare workers and patients
时间窗: 24 months
To investigate SARS-CoV-2 susceptibility by examining the number of positive SARS-CoV-2 result per participant
SARS-CoV-2 transmission in healthcare workers and patients
时间窗: 24 months
To investigate SARS-CoV-2 transmission by analysis of samples sequencing data from each study centre and across study centres
SARS-CoV-2 severity in healthcare workers and patients
时间窗: 24 months
To investigate SARS-CoV-2 severity by review of any hospital admissions
次要结局
未报告次要终点