Probing Language Processes Using Transcranial Magnetic Stimulation
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Stroke
- 发起方
- Medical College of Wisconsin
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Accuracy on language task performance
- 状态
- 招募中
- 最后更新
- 11个月前
概览
简要总结
This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
详细描述
To examine the brain's structure and specific language function and interactive relationships, investigators will implement repetitive or rapid TMS protocols in an active (or sham)-controlled, within-subject, randomized studies. Aims will evaluate the effects of short-term changes on each of the semantic or phonological language process of interest in isolation and changes in the interaction between language sub-processes and their interaction with other cognitive domains that directly or indirectly affect language functions. The brain targets for TMS application will be informed by existing evidence on (correlational but not causal) associations between language regions and specific language processes from numerous prior neuroimaging (e.g., functional magnetic resonance imaging or fMRI) and neuropsychological studies. Healthy individuals and/or stroke survivors with aphasia will be recruited to address these aims.
研究者
Priyanka Shah-Basak, PhD
Assistant Professor
Medical College of Wisconsin
入排标准
入选标准
- •Diagnosed with left hemisphere stroke
- •Consent date \>= 1 month after stroke onset
- •Right-handed
- •Fluent in English
- •18 years of age or older
排除标准
- •Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
- •Non-decisional per decisionality questionnaire or other clinical assessment
- •Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
- •A chronic medical condition that is not treated or is unstable
- •Presence of
- •cardiac stimulators or pacemakers or intracardiac lines
- •neurostimulators
- •medication infusion device
- •any other implants near the scalp (e.g., cochlear implants) or in the eye
- •metal in the body
结局指标
主要结局
Accuracy on language task performance
时间窗: Language tasks administered immediately before and/or after TMS administration (same day).
Improvement on language task performance as measured by increase in accuracy.
Reaction time on language task performance
时间窗: Language tasks administered immediately before and/or after TMS administration (same day).
Improvement on language task performance as measured by decrease in reaction time.