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临床试验/NCT05729841
NCT05729841已完成不适用

StORMM 1:What Effect Does Rowing 3000 Miles Across Atlantic Ocean Have on Calf Muscle Size? StORMM 2. In the Catabolic State of Extreme Endurance, is Muscle Loss Uniform or Can the Human Body Select Depending on Load and Nutrient Availability?

University of Exeter1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2020年11月28日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
1
主要终点
Calf Muscle thickness

研究概览

简要总结

Little is known on the human adaptation to extreme endurance and with the increasing popularity in long duration events we seek to provide insight into the physiological and metabolic adaptation processes of ocean rowing.

Rowing 12-18 hours a day will illicit a high energy expenditure and anecdotally people have lost large amounts of body weight and variable amounts of muscle mass, particularly in the lower limbs. This may provide insights and a potential new model to to study muscle unloading.

详细描述

Previous research has investigated factors determining muscle loss through bed rest and limb immobilisation. These methods are limited in that some do not include inflammation or changes in nutrition, which have been shown to be key drivers of muscle loss. These studies aim to investigate a potentially new model of muscle unloading.

Ocean rowing is an ultra-endurance sport where people spend 35-90 days at sea. Usually rowing for a minimum of 12 hours a day, in a 2-hour on/off shift pattern with daily food rations. Rowers lose body and muscle mass. There is likely to be low-grade inflammation, nutritional deficit, fatigue and rowers do not stand up for the entire crossing. Part 1 aims to quantify this muscle loss by inviting rowers in the annual 3000 mile Talisker Whisky Atlantic Challenge 2020 to take part. While part 2 aims to continue the work by measuring upper and core muscles as well as lower limb muscles from the first study with the aim of understanding how the body allocates resources in a hypocaloric, high energy expenditure environment.

Muscle mass of the lower limbs of the rowers will be measured with ultrasound, as well as body mass, body composition, energy expenditure and nutritional intake, the week before the race and immediately after arrival in Antigua. As well as adding novel insights to the knowledge base around factors affecting ultra endurance performance, the results will then be used to inform future intervention studies aimed at preventing muscle loss.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Taking part in the Talisker Whisky Atlantic Challenge 2020 and 2021

排除标准

  • lower limb amputee musculoskeletal, metabolic, neurological disease pacemaker fitted

结局指标

主要结局

Calf Muscle thickness

时间窗: 5-7 weeks

Pre - Post measurements of calf muscle thickness

Energy Intake

时间窗: 5-7 days in final week of row

Amount of kcals consumed per day

Energy Expenditure

时间窗: 5-7 days in final week of row

Amount of kcals expended per day

次要结局

  • Difference in rate of muscle thickness loss in older vs younger rowers(5-7 weeks)
  • Difference in rate of muscle thickness loss between males and females(5-7 weeks)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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