Machine-perfusion for Liver Transplantation in High Versus Low/Mid-volume Centres: an International Multicentre Survey
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Liver transplant(LT) centres different use of graft after utilization of machine perfusion (MP)
研究概览
简要总结
Introduction: Machine perfusion (MP) was developed to expand the available donor pool and to improve liver transplantation outcomes. Despite optimal results in clinical trials, MP benefit outside of clinical experimentation in unknown. Low/mid volume centres (L/MVCs) may face logistical/economical difficulties that may in turn hamper optimal MP results.
Methods: An Online 22-item survey on the use of machine perfusion for liver transplantation outside of clinical trials, was distributed to worldwide LT centres representatives. Variables of interest included MP logistics, MP technicalities, MP results, post-MP LT results. Responding centres were grouped into high volume centre (HVCs)(defined as >60 LTs per year in 2019) and L/MVCs. Results from HVCs vs L/MVCs were compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •LT centres that use MP
- •LT centres which perform LT before pandemic time (before 2019 included)
- •LT centres which perform LT from cadaveric donors and living donors
排除标准
- •LT centres that not use MP
- •LT centres that use MP but on clinical trials
结局指标
主要结局
Liver transplant(LT) centres different use of graft after utilization of machine perfusion (MP)
时间窗: 12/2021 - 03/2022
High Volume Centers and Low/Mid Volume centers differ in their rates of graft utilization after Machine perfusion
次要结局
- Liver Transplant outcomes after Machine Perfusion(12/2021 - 03/2022)
研究者
Roberta Angelico
Principal investigator, Professor, MD, PhD, FEBS
University of Rome Tor Vergata